Shahid Bukhari, Stephen Hughes, Nabeela Mughal, Luke S P Moore, Gary Davies, Adrian Vargas Zhang, Megan Ng, Zekiye Karagozlu, Marta Boffito
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引用次数: 0
Abstract
Background: In the UK, a regional vertical system for the delivery of COVID-19 medicines has been in place. This enabled centralization of expertise in risk stratification of patients, and in understanding and mitigating drug-drug interactions.
Research design and methods: We analyzed real-world drug-drug interactions in adult patients referred for nirmatrelvir/ritonavir therapy across one such geographic area covering 2.2 million London citizens.
Results: Among 208 who received NMV/r therapy, we identified 184 potential DDIs, 8% precluded nirmatrelvir/ritonavir use, 53% required management, but 56% of these did not have documented advice to hold therapy.
Conclusions: This highlights the need to maintain and develop pathways for clinical pharmacology expertise in COVID-19 management.
期刊介绍：
Expert Review of Anti-Infective Therapy (ISSN 1478-7210) provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.
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