Targeting Androgen Receptor Alterations in Metastatic Prostate Cancer.

IF 5.4 3区 材料科学 Q2 CHEMISTRY, PHYSICAL
Pawel Rajwa, Piotr Zapała, Axel S Merseburger
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引用次数: 0

Abstract

There have been significant advances in our understanding of the biology of metastatic prostate cancer (mPCa) and its response to therapy. Androgen receptor (AR) alterations, including mutations, amplifications, splice variants, and alternative activations, play a significant role in mPCa resistance to treatment. Recent studies indicate that AR alterations detected via genomic testing can be considered predictive biomarkers in men with castration-resistant PCa and can guide treatment strategies. Novel therapeutic approaches, including AR antagonists and inhibitors of ACK1, the AR N-terminal domain, or cytochrome P450 11A1, have shown promise in overcoming treatment resistance. Ongoing clinical trials are exploring the efficacy of these treatments in relation to AR mutation status and could potentially transform the treatment landscape for mPCa. PATIENT SUMMARY: Our mini review highlights advances in the treatment of metastatic prostate cancer, with a focus on drugs that target genetic alterations affecting a protein called the androgen receptor. Some promising results have been obtained and clinical trials are ongoing.

针对转移性前列腺癌中的雄激素受体改变。
我们对转移性前列腺癌(mPCa)的生物学特性及其治疗反应的了解取得了重大进展。雄激素受体(AR)的改变,包括突变、扩增、剪接变异和替代活化,在前列腺癌的耐药性中起着重要作用。最近的研究表明,通过基因组检测发现的AR改变可被视为男性阉割耐药PCa患者的预测性生物标志物,并可指导治疗策略。新的治疗方法,包括AR拮抗剂和ACK1、AR N-末端结构域或细胞色素P450 11A1的抑制剂,已显示出克服耐药性的希望。目前正在进行的临床试验正在探索这些治疗方法的疗效与AR突变状态的关系,并有可能改变mPCa的治疗格局。患者摘要:我们的微型综述重点介绍了转移性前列腺癌的治疗进展,重点是针对影响雄激素受体蛋白基因改变的药物。目前已经取得了一些有希望的结果,临床试验正在进行中。
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来源期刊
ACS Applied Energy Materials
ACS Applied Energy Materials Materials Science-Materials Chemistry
CiteScore
10.30
自引率
6.20%
发文量
1368
期刊介绍: ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.
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