Enantiomeric Analysis of Chiral Drugs Using Mass Spectrometric Methods: A Comprehensive Review

IF 2.8 4区化学 Q2 CHEMISTRY, ANALYTICAL

Chirality Pub Date : 2024-08-06 DOI:10.1002/chir.23705

Bhaskar Vallamkonda, Sonika Sethi, PhanikumarReddy Satti, Dipak Kumar Das, Suman Yadav, Vinod Kumar Vashistha

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Abstract

Chirality plays a crucial role in the drug development process, influencing fundamental chemical and biochemical processes and significantly affecting our daily lives. This review provides a comprehensive examination of mass spectrometric (MS) methods for the enantiomeric analysis of chiral drugs. It thoroughly investigates MS-hyphenated techniques, emphasizing their critical role in achieving enantioselective analysis. Furthermore, it delves into the intricate chiral recognition mechanisms inherent in MS, elucidating the fundamental principles that govern successful chiral separations. By critically assessing the obstacles and potential benefits associated with each MS-based method, this review offers valuable insights for researchers navigating the complexities of chiral analysis. Both qualitative and quantitative approaches are explored, presenting a comparative analysis of their strengths and limitations. This review is aimed at significantly enhancing the understanding of chiral MS methods, serving as a crucial resource for researchers and practitioners engaged in enantioselective studies.

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使用质谱方法分析手性药物的对映体：全面综述。

手性在药物开发过程中起着至关重要的作用，影响着基本的化学和生化过程，并对我们的日常生活产生重大影响。本综述全面探讨了用于手性药物对映体分析的质谱 (MS) 方法。它深入研究了质谱联用技术，强调了它们在实现对映体选择性分析中的关键作用。此外，它还深入探讨了 MS 固有的复杂手性识别机制，阐明了成功进行手性分离的基本原则。通过批判性地评估与每种基于 MS 的方法相关的障碍和潜在优势，本综述为研究人员驾驭复杂的手性分析提供了宝贵的见解。本综述探讨了定性和定量方法，并对其优势和局限性进行了比较分析。本综述旨在极大地提高对手性 MS 方法的理解，为从事对映选择性研究的研究人员和从业人员提供重要资源。

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来源期刊

Chirality 医学-分析化学

CiteScore

4.40

自引率

5.00%

发文量

124

审稿时长

1 months

期刊介绍： The main aim of the journal is to publish original contributions of scientific work on the role of chirality in chemistry and biochemistry in respect to biological, chemical, materials, pharmacological, spectroscopic and physical properties. Papers on the chemistry (physiochemical, preparative synthetic, and analytical), physics, pharmacology, clinical pharmacology, toxicology, and other biological aspects of chiral molecules will be published.