The impact of homocysteine on patients with diabetic nephropathy: a mendelian randomization study.

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Acta Diabetologica Pub Date : 2024-08-06 DOI:10.1007/s00592-024-02343-9

Baiju Wang, Han Li, Na Wang, Yuan Li, Zihua Song, Yajuan Chen, Xiaobing Li, Lei Liu, Hanwen Chen

{"title":"The impact of homocysteine on patients with diabetic nephropathy: a mendelian randomization study.","authors":"Baiju Wang, Han Li, Na Wang, Yuan Li, Zihua Song, Yajuan Chen, Xiaobing Li, Lei Liu, Hanwen Chen","doi":"10.1007/s00592-024-02343-9","DOIUrl":null,"url":null,"abstract":"Background/aims: Homocysteine (Hcy) has been associated with an increased risk of diabetic nephropathy (DN) in patients, but there is still controversy. This study aims to investigate the causal relationship between plasma Hcy and DN.Methods: A Mendelian randomization (MR) study using data from 2 samples was employed to infer causal relationships. The aggregated genetic data associated with Hcy was derived from the largest genome-wide association study (GWAS) to date, involving 44,147 individuals of European ancestry.Data on SNP-diabetic nephropathy, creatinine, and urea nitrogen were obtained from the IEU GWAS database. The analysis method employed a fixed-effect or random-effect inverse variance-weighted approach to estimate effects.Additional analysis methods were used to assess stability and sensitivity. The potential for pleiotropy was evaluated using the MR-Egger intercept test.Results: Using 12 SNPs as instrumental variables, two-sample MR analysis revealed no evidence of a causal relationship between genetically predicted plasma Hcy levels and diabetic nephropathy, as well as creatinine and blood urea nitrogen levels. This finding is consistent with the results obtained from other testing methods.Conclusions: Two-sample Mendelian Randomization analysis found no evidence of a causal relationship between plasma homocysteine levels and diabetic nephropathy, creatinine, or urea.","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Diabetologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00592-024-02343-9","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Background/aims: Homocysteine (Hcy) has been associated with an increased risk of diabetic nephropathy (DN) in patients, but there is still controversy. This study aims to investigate the causal relationship between plasma Hcy and DN.

Methods: A Mendelian randomization (MR) study using data from 2 samples was employed to infer causal relationships. The aggregated genetic data associated with Hcy was derived from the largest genome-wide association study (GWAS) to date, involving 44,147 individuals of European ancestry.Data on SNP-diabetic nephropathy, creatinine, and urea nitrogen were obtained from the IEU GWAS database. The analysis method employed a fixed-effect or random-effect inverse variance-weighted approach to estimate effects.Additional analysis methods were used to assess stability and sensitivity. The potential for pleiotropy was evaluated using the MR-Egger intercept test.

Results: Using 12 SNPs as instrumental variables, two-sample MR analysis revealed no evidence of a causal relationship between genetically predicted plasma Hcy levels and diabetic nephropathy, as well as creatinine and blood urea nitrogen levels. This finding is consistent with the results obtained from other testing methods.

Conclusions: Two-sample Mendelian Randomization analysis found no evidence of a causal relationship between plasma homocysteine levels and diabetic nephropathy, creatinine, or urea.

Abstract Image

查看原文本刊更多论文

同型半胱氨酸对糖尿病肾病患者的影响：一项孟德尔随机研究。

背景/目的：同型半胱氨酸（Hcy）与患者糖尿病肾病（DN）风险增加有关，但仍存在争议。本研究旨在探讨血浆 Hcy 与 DN 之间的因果关系：方法：使用两个样本的数据进行孟德尔随机化（MR）研究，以推断因果关系。与 Hcy 相关的综合遗传数据来自迄今为止最大的全基因组关联研究（GWAS），涉及 44,147 名欧洲血统的个体。SNP-糖尿病肾病、肌酐和尿素氮的数据来自 IEU GWAS 数据库。分析方法采用固定效应或随机效应反方差加权法来估计效应。使用MR-Egger截距检验评估了多向性的可能性：使用 12 个 SNP 作为工具变量，双样本 MR 分析显示，没有证据表明基因预测的血浆 Hcy 水平与糖尿病肾病以及肌酐和血尿素氮水平之间存在因果关系。这一结果与其他测试方法得出的结果一致：结论：双样本孟德尔随机分析没有发现血浆同型半胱氨酸水平与糖尿病肾病、肌酐或尿素之间存在因果关系的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta Diabetologica 医学-内分泌学与代谢

CiteScore

7.30

自引率

2.60%

发文量

180

审稿时长

2 months

期刊介绍： Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.