Coexistence of high visceral fat area and sarcopenia is associated with atherosclerotic markers in old-old patients with diabetes: A cross-sectional study

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2024-08-06 DOI:10.1111/jdi.14274

Motoya Sato, Yoshiaki Tamura, Yuji Murao, Fumino Yorikawa, Yuu Katsumata, So Watanabe, Shugo Zen, Remi Kodera, Kazuhito Oba, Kenji Toyoshima, Yuko Chiba, Atsushi Araki

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Abstract

Aims/Introduction

To investigate whether sarcopenic obesity is associated with the progression of atherosclerotic lesions in older patients with diabetes and to identify the obesity components of sarcopenic obesity that best reflect atherosclerosis.

Materials and Methods

In 118 inpatients aged ≥75 years with diabetes mellitus, sarcopenia defined as a low skeletal muscle mass and low grip strength was assessed, and sarcopenia coexisting with a high body-fat percentage or visceral fat area was defined as sarcopenic obesity. Correlations between the obesity components and atherosclerotic markers, including the carotid intima-media thickness, were analyzed; the intima-media thickness was analyzed in four groups with and without obesity and sarcopenia, and a multiple linear regression analysis adjusted for covariates was conducted to investigate whether sarcopenic obesity was independently associated with the intima-media thickness.

Results

The visceral fat area and intima-media thickness showed positive correlations in the overall patients (P = 0.032) and the sarcopenia (P = 0.016) group but showed no associations in participants without sarcopenia. The intima-media thickness in the group showing sarcopenia with a high visceral fat area was significantly higher than that in the control group (P = 0.012). Sarcopenic obesity defined by a high body-fat percentage and high visceral fat area was independently associated with the intima-media thickness even after adjusting for age, sex, and atherogenic risk factors. However, sarcopenic obesity defined by a high visceral fat area was more strongly associated with the intima-media thickness (β = 0.384, P = 0.002) than that defined by the high body-fat percentage (β = 0.237, P = 0.068).

Conclusions

Sarcopenic obesity, especially that defined by visceral fat accumulation, reflected the risk of atherosclerotic lesion progression in older patients with diabetes.

Abstract Image

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高内脏脂肪面积和肌肉疏松症并存与老年糖尿病患者的动脉粥样硬化标志物有关：一项横断面研究

目的/简介：研究肌肉疏松性肥胖是否与老年糖尿病患者动脉粥样硬化病变的进展有关，并确定肌肉疏松性肥胖中最能反映动脉粥样硬化的肥胖成分：在118名年龄≥75岁的糖尿病住院患者中，评估了以骨骼肌质量低和握力低为定义的肌肉疏松症，并将肌肉疏松症与高体脂率或内脏脂肪面积并存定义为肌肉疏松性肥胖。分析了肥胖成分与动脉粥样硬化标志物（包括颈动脉内膜厚度）之间的相关性；分析了有无肥胖和肌肉疏松症的四组颈动脉内膜厚度，并进行了调整协变量的多元线性回归分析，以研究肌肉疏松性肥胖是否与颈动脉内膜厚度独立相关：结果：内脏脂肪面积和血管内膜厚度在总体患者组（P = 0.032）和肌肉疏松症组（P = 0.016）中呈正相关，但在无肌肉疏松症的参与者中则没有相关性。内脏脂肪含量高的肌肉疏松症组的血管内中膜厚度明显高于对照组（P = 0.012）。即使在调整了年龄、性别和致动脉粥样硬化风险因素后，由高体脂率和高内脏脂肪面积定义的肌肉疏松性肥胖与血管内膜厚度仍有独立关联。然而，与高体脂百分比（β = 0.237，P = 0.068）相比，由高内脏脂肪面积定义的肌肉疏松性肥胖与中层内膜厚度的相关性更强（β = 0.384，P = 0.002）：结论：肌肉松弛性肥胖，尤其是由内脏脂肪堆积定义的肌肉松弛性肥胖，反映了老年糖尿病患者动脉粥样硬化病变进展的风险。

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来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).