This study presents a multiobjective optimization framework that integrates Artificial Neural Network (ANN) and Non-dominated Sorting Genetic Algorithm-II (NSGA-II) for the optimization of rolling process parameters of tube-to-tubesheet joint (TTT-joint). During the rolling process, both beneficial contact pressure and detrimental tensile residual stress are generated within the joint. The primary objective of this framework is to minimize the tensile residual stress while maximizing the contact pressure in the TTT-joint. To achieve this, a backpropagation ANN model is trained to rapidly estimate the residual stress and contact pressure for various sets of rolling process parameters. For training purposes, a series of nonlinear elastoplastic finite element (FE) simulations are performed to generate the input database for the neural network. A detailed parametric study is performed based on the axisymmetric FE model of the TTT-joint. The trained neural network is then incorporated into the NSGA-II optimization algorithm to find the fitness function and optimized process parameters. The contact pressure and residual stress predicted by the proposed ANN-NSGA-II framework are validated by finite element analysis (FEA) using the optimized parameters. The present analysis established that the proposed methodology can be applied in practical engineering problems to obtain the process parameters that yield the maximum contact pressure and minimum tensile residual stress in the TTT-joint.