The relationship between serum uric acid level and carotid intima-media thickness in hemodialysis patients

IF 1.2 4区 医学 Q3 UROLOGY & NEPHROLOGY
Ali Veysel Kara, Hamza Inan, Onder Durmaz, Ridvan Ozdemir
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引用次数: 0

Abstract

Introduction

We aimed to evaluate the relationship between carotid intima-media thickness (CIMT), which is a known indicator of cardiovascular risk and atherosclerosis, and uric acid level, which may be an easy marker for cardiovascular diseases due to its antioxidant and pro-oxidant properties in hemodialysis patients.

Methods

In this cross-sectional study, we evaluated 77 hemodialysis patients. The mean CIMT of these patients was measured and recorded by Doppler ultrasonography. Patients were divided into two groups according to their serum uric acid levels. Correlation analysis and linear regression analysis were used to define the relationship between study parameters.

Findings

The mean CIMT levels in the normouricemic group and the hyperuricemic group were 0.95 ± 0.15 and 1.07 ± 0.15, respectively. There was a statistically significant difference between the two groups (p = 0.001). There was a statistically significant and moderate linear correlation between serum uric acid level and mean CIMT (r = 0.402; p = 0.002). Univariate and multivariate linear regression analyses were performed to identify variables that could independently affect the mean CIMT value. According to analysis, uric acid (p < 0.001), hypertension (p = 0.008), albumin (p = 0.029), and C-reactive protein (p = 0.042) were found independent risk factors for mean CIMT value.

Discussion

We found a significant relationship between serum uric acid level and CIMT, which indicates carotid atherosclerosis. Serum uric acid level is a low-cost laboratory parameter that can be measured in almost all laboratories, and it may be valuable in the hemodialysis patient group to identify patients at high risk of carotid atherosclerosis.

血液透析患者血清尿酸水平与颈动脉内膜中层厚度的关系。
导言我们旨在评估血液透析患者颈动脉内膜中层厚度(CIMT)(已知的心血管风险和动脉粥样硬化指标)与尿酸水平之间的关系:在这项横断面研究中,我们对 77 名血液透析患者进行了评估。多普勒超声测量并记录了这些患者的平均 CIMT。根据血清尿酸水平将患者分为两组。采用相关分析和线性回归分析来确定研究参数之间的关系:结果:正常尿酸血症组和高尿酸血症组的平均 CIMT 水平分别为 0.95 ± 0.15 和 1.07 ± 0.15。两组之间的差异具有统计学意义(P = 0.001)。血清尿酸水平与平均 CIMT 之间存在统计学意义上的中度线性相关(r = 0.402; p = 0.002)。进行了单变量和多变量线性回归分析,以确定可能独立影响平均 CIMT 值的变量。分析结果表明,尿酸(P 讨论)、血清胆固醇(P我们发现血清尿酸水平与 CIMT 之间存在明显关系,而 CIMT 则表明颈动脉粥样硬化。血清尿酸水平是一种成本低廉的实验室参数,几乎所有实验室都能测量,它可能对血液透析患者群体识别颈动脉粥样硬化高风险患者很有价值。
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来源期刊
Hemodialysis International
Hemodialysis International UROLOGY & NEPHROLOGY-
CiteScore
2.50
自引率
0.00%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Hemodialysis International was originally an annual publication containing the Proceedings of the International Symposium on Hemodialysis held in conjunction with the Annual Dialysis Conference. Since 2003, Hemodialysis International is published quarterly and contains original papers on clinical and experimental topics related to dialysis in addition to the Annual Dialysis Conference supplement. This journal is a must-have for nephrologists, nurses, and technicians worldwide. Quarterly issues of Hemodialysis International are included with your membership to the International Society for Hemodialysis. The journal contains original articles, review articles, and commentary to keep readers completely updated in the field of hemodialysis. Edited by international and multidisciplinary experts, Hemodialysis International disseminates critical information in the field.
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