Mesenchymal stem cell–derived extracellular vesicles in joint diseases: Therapeutic effects and underlying mechanisms

IF 5.9 1区医学 Q1 ORTHOPEDICS

Journal of Orthopaedic Translation Pub Date : 2024-07-27 DOI:10.1016/j.jot.2024.07.005

Jinhui Wu , Jiangyi Wu , Zheng Liu , Yunquan Gong , Daibo Feng , Wei Xiang , Shunzheng Fang , Ran Chen , Yaran Wu , Shu Huang , Yizhao Zhou , Ningning Liu , Hao Xu , Siru Zhou , Baorong Liu , Zhenhong Ni

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引用次数: 0

Abstract

Joint diseases greatly impact the daily lives and occupational functioning of patients globally. However, conventional treatments for joint diseases have several limitations, such as unsatisfatory efficacy and side effects, necessitating the exploration of more efficacious therapeutic strategies. Mesenchymal stem cell (MSC)-derived EVs (MSC-EVs) have demonstrated high therapeutic efficacyin tissue repair and regeneration, with low immunogenicity and tumorigenicity. Recent studies have reported that EVs-based therapy has considerable therapeutic effects against joint diseases, including osteoarthritis, tendon and ligament injuries, femoral head osteonecrosis, and rheumatoid arthritis. Herein, we review the therapeutic potential of various types of MSC-EVs in the aforementioned joint diseases, summarise the mechanisms underlying specific biological effects of MSC-EVs, and discuss future prospects for basic research on MSC-EV-based therapeutic modalities and their clinical translation. In general, this review provides an in-depth understanding of the therapeutic effects of MSC-EVs in joint diseases, as well as the underlying mechanisms, which may be beneficial to the clinical translation of MSC-EV-based treatment.

The translational potential of this article: MSC-EV-based cell-free therapy can effectively promote regeneration and tissue repair. When used to treat joint diseases, MSC-EVs have demonstrated desirable therapeutic effects in preclinical research. This review may supplement further research on MSC-EV-based treatment of joint diseases and its clinical translation.

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间充质干细胞衍生的细胞外囊泡在关节疾病中的作用：治疗效果和潜在机制

关节疾病严重影响着全球患者的日常生活和职业功能。然而，关节疾病的传统治疗方法存在一些局限性，如疗效不理想、副作用大等，因此有必要探索更有效的治疗策略。间充质干细胞（MSC）衍生的EVs（MSC-EVs）在组织修复和再生方面具有很高的疗效，而且免疫原性和致肿瘤性较低。最近有研究报告称，基于EVs的疗法对关节疾病（包括骨关节炎、肌腱和韧带损伤、股骨头坏死和类风湿性关节炎）具有显著的治疗效果。在此，我们综述了各类间充质干细胞-EVs 在上述关节疾病中的治疗潜力，总结了间充质干细胞-EVs 特定生物效应的机制，并讨论了基于间充质干细胞-EVs 治疗模式的基础研究及其临床转化的未来前景。总之，本综述使人们对间充质干细胞-EVs在关节疾病中的治疗作用及其机制有了深入的了解，这可能有利于基于间充质干细胞-EVs的治疗方法的临床转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Orthopaedic Translation Medicine-Orthopedics and Sports Medicine

CiteScore

11.80

自引率

13.60%

发文量

审稿时长

29 days

期刊介绍： The Journal of Orthopaedic Translation (JOT) is the official peer-reviewed, open access journal of the Chinese Speaking Orthopaedic Society (CSOS) and the International Chinese Musculoskeletal Research Society (ICMRS). It is published quarterly, in January, April, July and October, by Elsevier.