Long He, Jing Huang, Xingxing Zhang, Tianbing Ren, Prof. Lin Yuan
{"title":"Asymmetric π-Extension Design of Long Wavelength Rhodamine Derivatives for Imaging and Phototherapy","authors":"Long He, Jing Huang, Xingxing Zhang, Tianbing Ren, Prof. Lin Yuan","doi":"10.1002/cptc.202400191","DOIUrl":null,"url":null,"abstract":"<p>Rhodamine dyes have been extensively explored for bioimaging and therapeutic applications over the past few decades. However, it remains a challenge to design long-wavelength and large Stokes shift rhodamine derivatives to meet the requirements of fluorescence imaging and phototherapy in deep living tissues. In this work, a pyridine aromatic unit was inserted into the rhodamine derivatives (AC-Fluor: ACF) skeleton to prepare a series of stable rhodamine derivatives, named ACFPs, to achieve long emission wavelength (>650 nm) and large Stokes shift (~60 nm) by tuning the conjugated systems and electronic symmetry. Moreover, ACFPs are capable of continuously producing superoxide radical (O<sub>2</sub><sup>−</sup>⋅) under long wavelength irradiation. This study presents a novel paradigm for improving the optical properties of rhodamine, which has led to the development of a novel tool for image-guided phototherapy for cancer treatment.</p>","PeriodicalId":10108,"journal":{"name":"ChemPhotoChem","volume":"8 12","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemPhotoChem","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cptc.202400191","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Rhodamine dyes have been extensively explored for bioimaging and therapeutic applications over the past few decades. However, it remains a challenge to design long-wavelength and large Stokes shift rhodamine derivatives to meet the requirements of fluorescence imaging and phototherapy in deep living tissues. In this work, a pyridine aromatic unit was inserted into the rhodamine derivatives (AC-Fluor: ACF) skeleton to prepare a series of stable rhodamine derivatives, named ACFPs, to achieve long emission wavelength (>650 nm) and large Stokes shift (~60 nm) by tuning the conjugated systems and electronic symmetry. Moreover, ACFPs are capable of continuously producing superoxide radical (O2−⋅) under long wavelength irradiation. This study presents a novel paradigm for improving the optical properties of rhodamine, which has led to the development of a novel tool for image-guided phototherapy for cancer treatment.
ChemPhotoChemChemistry-Physical and Theoretical Chemistry
CiteScore
5.80
自引率
5.40%
发文量
165
期刊介绍:
Light plays a crucial role in natural processes and leads to exciting phenomena in molecules and materials. ChemPhotoChem welcomes exceptional international research in the entire scope of pure and applied photochemistry, photobiology, and photophysics. Our thorough editorial practices aid us in publishing authoritative research fast. We support the photochemistry community to be a leading light in science.
We understand the huge pressures the scientific community is facing every day and we want to support you. Chemistry Europe is an association of 16 chemical societies from 15 European countries. Run by chemists, for chemists—we evaluate, publish, disseminate, and amplify the scientific excellence of chemistry researchers from around the globe.