Sixteen-year outcomes of patients undergoing minimally invasive direct coronary artery bypass surgery: a single-center experience

Oluwanifemi Akintoye, Aabha Divya, Shakil Farid, Samer Nashef, Ravi De Silva
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Abstract

Minimally invasive direct coronary artery bypass (MIDCAB) grafting is a safe technique for revascularization of the left anterior descending artery. The objective of this study was to evaluate the long-term outcomes of patients who underwent MIDCAB surgery in our institution. This was a retrospective, observational outcome study of retrospectively collected data. Data was collected using community, electronic, and paper medical records as well as telephone follow-up conversations with patients who underwent MIDCAB between December 1996 and June 2021. The primary outcome measure was mortality. Secondary outcomes included revascularization, myocardial infarction, and wound infection. Survival analysis was performed using the Kaplan–Meier method. A total of 215 patients were identified in the study period undergoing MIDCAB at our center. The median age was 77 years, and the cohort consisted of 180 (83.3%) of male patients. The median follow-up period was 16 years (12.1–17.7). At follow-up, freedom from repeat left anterior descending revascularization and from other vessels, revascularization was 96.7% and 89.1% respectively. Survival rates were 99.5%, 81.0%, and 45.2% survival at 1 year, 10 years, and 25 years respectively. Univariate analysis showed age (p < 0.01, Hazard ratio 1.08 confidence interval 1.05–1.11) and left ventricular function (p < 0.01, hazard ratio 2.40, confidence interval 1.66–3.45) as factors associated with mortality. Our single-center experience of MIDCAB demonstrated excellent long-term freedom from revascularization and other complications. Although limited by the retrospective nature, the study shows MIDCAB to be a safe procedure for definitive revascularization of the left anterior descending coronary artery.
接受微创直接冠状动脉搭桥手术患者的 16 年疗效:单中心经验
微创直接冠状动脉搭桥术(MIDCAB)是一种安全的左前降支动脉再血管化技术。本研究旨在评估在我院接受 MIDCAB 手术的患者的长期疗效。这是一项对回顾性数据进行的回顾性观察结果研究。数据通过社区、电子和纸质病历以及与 1996 年 12 月至 2021 年 6 月间接受 MIDCAB 手术患者的电话随访交谈收集。主要结果是死亡率。次要结果包括血管再通、心肌梗死和伤口感染。采用 Kaplan-Meier 法进行生存分析。研究期间,共有 215 名患者在本中心接受了 MIDCAB 手术。中位年龄为 77 岁,其中男性患者 180 名(83.3%)。中位随访时间为 16 年(12.1-17.7)。随访期间,不再接受左前降支血管再通手术和不再接受其他血管再通手术的比例分别为96.7%和89.1%。1年、10年和25年的存活率分别为99.5%、81.0%和45.2%。单变量分析显示,年龄(P < 0.01,危险比 1.08,置信区间 1.05-1.11)和左心室功能(P < 0.01,危险比 2.40,置信区间 1.66-3.45)是死亡率的相关因素。我们单中心的 MIDCAB 经验表明,患者长期无血运重建和其他并发症。虽然这项研究具有回顾性的局限性,但它表明 MIDCAB 是一种安全的冠状动脉左前降支明确再通术。
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