Effect of dose to parotid ducts on Sticky Saliva and Xerostomia in radiotherapy of head and neck squamous cell carcinoma.

IF 3.3 2区医学 Q2 ONCOLOGY

Radiation Oncology Pub Date : 2024-08-02 DOI:10.1186/s13014-024-02495-6

Daniel H Schanne, Dominik U Alder, Jana Lippmann, Daniel M Aebersold, Olgun Elicin

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引用次数: 0

Abstract

Background: Radiotherapy (RT) in head and neck squamous cell cancer (HNSCC) often leads to sticky saliva and xerostomia (SSX). Dose sparing of salivary glands (SG) reduces occurrence of SSX but few studies investigated the relationship between RT dose to SG substructures and SSX. We therefore investigated this hypothesis, focusing on the parotid duct (PD).

Methods: Retrospective data was collected from 99 HNSCC patients treated at our center with (chemo-)radiotherapy (CRT). PD and other organs-at-risk (OAR) were (re-)contoured and DVHs were generated without re-planning. SSX was graded according to CTCAE v.4.03 and evaluated at acute, subacute, and two late timepoints.

Results: Most patients presented with loco-regionally advanced disease. In 47% of patients, up-front neck dissection preceded CRT. Weighted mean dose was 28.6 Gy for bilateral parotid glands (PG), and 32.0 Gy for PD. Acute SSX presented as grades 0 (35.3%), I (41.4%), II (21.2%) and III (2.0%). There was no association of OARs and SSX ≥ grade 2 in univariable logistic regression (LR). Multivariable LR showed statistically significant relationship of acute SSX with: PG weighted mean dose (OR 0.84, p = 0.004), contralateral PG mean dose (OR 1.14, p = 0.02) and contralateral PD planning OAR (PD PRV) mean dose (OR 1.84, p = 0.03).

Conclusions: There was an association of acute SSX with dose exposure of PD PRV in multivariable regression, only. Due to statistical uncertainties and the retrospective nature of this analysis, further studies are required to confirm or reject the hypothesis.

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腮腺导管剂量对头颈部鳞状细胞癌放疗中粘稠唾液和口臭的影响

背景：头颈部鳞状细胞癌（HNSCC）的放疗（RT）经常导致唾液粘稠和口干症（SSX）。唾液腺（SG）的剂量疏导可减少唾液粘稠和口臭的发生，但很少有研究调查唾液腺下结构的 RT 剂量与唾液粘稠和口臭之间的关系。因此，我们对这一假设进行了研究，重点是腮腺导管（PD）：我们从本中心接受（化疗）放疗（CRT）的 99 例 HNSCC 患者中收集了回顾性数据。对腮腺导管和其他危险器官（OAR）进行（重新）轮廓描绘，并在不重新规划的情况下生成 DVH。根据 CTCAE v.4.03 对 SSX 进行分级，并在急性、亚急性和两个晚期时间点进行评估：结果：大多数患者为局部区域晚期疾病。47%的患者在接受 CRT 治疗前进行了颈部切除术。双侧腮腺（PG）的加权平均剂量为28.6 Gy，PD为32.0 Gy。急性 SSX 分为 0 级（35.3%）、I 级（41.4%）、II 级（21.2%）和 III 级（2.0%）。在单变量逻辑回归（LR）中，OAR 与≥ 2 级的 SSX 没有关联。多变量 LR 显示急性 SSX 与以下因素有显著的统计学关系：PG加权平均剂量（OR 0.84，p = 0.004）、对侧PG平均剂量（OR 1.14，p = 0.02）和对侧PD计划OAR（PD PRV）平均剂量（OR 1.84，p = 0.03）：结论：仅在多变量回归中，急性SSX与PD PRV的剂量暴露有关。由于统计学上的不确定性和该分析的回顾性，需要进一步研究来证实或否定该假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiation Oncology ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

6.50

自引率

2.80%

发文量

181

审稿时长

3-6 weeks

期刊介绍： Radiation Oncology encompasses all aspects of research that impacts on the treatment of cancer using radiation. It publishes findings in molecular and cellular radiation biology, radiation physics, radiation technology, and clinical oncology.

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