Associations Between CYP3A5 (c.6986A>G) Gene Polymorphism and Kidney Impairment in Hypertensive Adults Without Cystatin C Elevation.

IF 3.4 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Toxicology Pub Date : 2024-10-01 Epub Date: 2024-08-02 DOI:10.1007/s12012-024-09902-0

Ling Chen, Yufeng Jiang, Xingbo Cheng

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Abstract

Objective: This study aimed to explore the potential role of CYP3A5 (c. 6986A>G) gene polymorphism in predicting kidney function impairment in patients with hypertension who did not have elevated serum cystatin C.

Methods: We recruited a group of patients with hypertension who did not have elevated cystatin C and analyzed the CYP3A5 (c. 6986A>G) gene polymorphism. Chi-square tests were used to compare the clinical characteristics and genotypic distribution between the two groups. Logistic regression analysis was used to explore the association between CYP3A5 (c.6986A>G) gene polymorphism and renal function impairment in hypertension with non-elevated cystatin.

Results: In patients with hypertension who participated in the study, there was a significant association between CYP3A5 (c. 6986A>G) gene polymorphism and kidney function impairment (p < 0.05). Patients with the CYP3A5 (c. 6986A>G) mutation display a greater risk of kidney function impairment.

Conclusion: CYP3A5 (c. 6986A>G) gene AA homozygote polymorphism significantly increases risk of kidney function impairment in patients with hypertension with normal cystatin C. However, further studies are needed to validate this association and to further understand the mechanism of CYP3A5 (c. 6986A>G) gene polymorphism in kidney function impairment in patients with hypertension.

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CYP3A5（c.6986A>G）基因多态性与无胱抑素 C 升高的高血压成人肾功能损害之间的关系

研究目的本研究旨在探讨CYP3A5（c. 6986A>G）基因多态性在预测血清胱抑素C未升高的高血压患者肾功能损害中的潜在作用：我们招募了一组未出现胱抑素 C 升高的高血压患者，并对其 CYP3A5 (c. 6986A>G)基因多态性进行了分析。采用卡方检验比较两组患者的临床特征和基因型分布。采用逻辑回归分析探讨胱抑素不升高的高血压患者CYP3A5（c.6986A>G）基因多态性与肾功能损害之间的关系：在参与研究的高血压患者中，CYP3A5（c. 6986A>G）基因多态性与肾功能损害之间存在显著关联（p G）突变显示肾功能损害的风险更大：CYP3A5（c. 6986A>G）基因AA同源多态性会显著增加胱抑素C正常的高血压患者肾功能损害的风险。然而，还需要进一步的研究来验证这种关联，并进一步了解CYP3A5（c. 6986A>G）基因多态性在高血压患者肾功能损害中的作用机制。

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来源期刊

Cardiovascular Toxicology 医学-毒理学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

>12 weeks

期刊介绍： Cardiovascular Toxicology is the only journal dedicated to publishing contemporary issues, timely reviews, and experimental and clinical data on toxicological aspects of cardiovascular disease. CT publishes papers that will elucidate the effects, molecular mechanisms, and signaling pathways of environmental toxicants on the cardiovascular system. Also covered are the detrimental effects of new cardiovascular drugs, and cardiovascular effects of non-cardiovascular drugs, anti-cancer chemotherapy, and gene therapy. In addition, Cardiovascular Toxicology reports safety and toxicological data on new cardiovascular and non-cardiovascular drugs.