Abnormal Functional Attributes of Central Executive Network in Patients with Mild Cognitive Impairment Associated with End-Stage Renal Disease

IF 3.8 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Academic Radiology Pub Date : 2025-03-01 DOI:10.1016/j.acra.2024.07.030

Wenqing Li , Wei Sun , Di Wang , Zhuqing Jiao , Tongqiang Liu , Wanchao Zhang , Haifeng Shi

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Abstract

Rationale and Objectives

To assess changes in the central executive network (CEN) of patients with mild cognitive impairment (MCI) associated with end-stage renal disease (ESRD).

Methods

A total of 121 patients with ESRD and 66 healthy controls (HCs) were enrolled. Patients were divided into an MCI group (n = 67) and a cognitively unimpaired group (n = 54). All participants underwent resting-state functional magnetic resonance imaging and were evaluated using the Montreal Cognitive Assessment (MoCA). The functional attributes of the CEN were calculated using three methods of functional connectivity (FC) analysis. Relationships among imaging features, cognitive scale scores, and clinical data were assessed, and a model was constructed to diagnose MCI in patients with ESRD.

Results

The comparison of the three groups showed that there were significant differences in the FC values of five connection pairs within the CEN, and the CEN demonstrated significant differences in connectivity to ten brain regions. In patients with MCI associated with ESRD, the information transmission efficiency of the CEN was reduced, which demonstrates the characteristics of a random network to some extent. Significant correlations were observed among imaging parameters, cognitive scale scores, and clinical data. The diagnostic model constructed based on these results demonstrated excellent discrimination and calibration.

Conclusion

Alterations in the function of the CEN provide relevant bases for revealing the neuropathological mechanism of MCI in patients with ESRD. The diagnostic model developed in this study may help to establish more reliable imaging markers for detecting early cognitive impairment in this patient population.

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与终末期肾病相关的轻度认知功能障碍患者的中央执行网络功能特征异常

理由和目标评估与终末期肾病（ESRD）相关的轻度认知障碍（MCI）患者的中央执行网络（CEN）的变化：方法：共招募了 121 名 ESRD 患者和 66 名健康对照组（HCs）。患者被分为 MCI 组（67 人）和认知功能未受损组（54 人）。所有参与者都接受了静息态功能磁共振成像检查，并使用蒙特利尔认知评估（MoCA）进行了评估。CEN 的功能属性是通过三种功能连接（FC）分析方法计算得出的。评估了成像特征、认知量表评分和临床数据之间的关系，并构建了ESRD患者MCI诊断模型：结果：三组患者的对比显示，CEN内五个连接对的FC值存在显著差异，CEN与十个脑区的连接也存在显著差异。在伴ESRD的MCI患者中，CEN的信息传输效率降低，这在一定程度上显示了随机网络的特征。成像参数、认知量表评分和临床数据之间存在显著相关性。根据这些结果构建的诊断模型显示出极佳的辨别能力和校准能力：结论：CEN 功能的改变为揭示 ESRD 患者 MCI 的神经病理机制提供了相关依据。本研究中建立的诊断模型可能有助于建立更可靠的成像标记，以检测这类患者的早期认知功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Academic Radiology 医学-核医学

CiteScore

7.60

自引率

10.40%

发文量

432

审稿时长

18 days

期刊介绍： Academic Radiology publishes original reports of clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, image-guided interventions and related techniques. It also includes brief technical reports describing original observations, techniques, and instrumental developments; state-of-the-art reports on clinical issues, new technology and other topics of current medical importance; meta-analyses; scientific studies and opinions on radiologic education; and letters to the Editor.