The effects of khat (Catha edulis) use on the genitourinary system: A systematic review and meta-analysis.

IF 1.1 4区医学 Q4 SUBSTANCE ABUSE

Journal of Ethnicity in Substance Abuse Pub Date : 2024-08-02 DOI:10.1080/15332640.2024.2382691

Faisal Ahmed, Ibrahim Alnadhari, Saif Ghabisha, Abdulfattah Altam, Abdullah Almatary, Basheer Ali Mahyoub Abdo, Ahmed Badheeb, Khaled Al-Kohlany, Abdulghani Al-Hagri

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引用次数: 0

Abstract

The objective of the current study is to conduct a meta-analysis of the existing literature concerning the potential impact of khat on the reproductive systems. Five international databases, Embase, Medline/PubMed, Scopus, Web of Knowledge (ISI), and ProQuest, were searched from inception up to the end of January 2024. The Joanna Briggs Institute (JBI) Critical Appraisal Checklist was used for quality assessment of included studies. After several screening phases,10 articles were included in the final analysis. The pooled meta-analysis showed that women who use khat during pregnancy had a significantly higher chance of having low birth weight (LBW) (OR= 2.51, 95% CI: 1.61-3.95, p-value < 0.001) and congenital anomalies (OR= 3.17, 95% CI: 1.31-7.73, p-value = 0.011) compared to nonusers. The obtained results of the meta-analysis showed that the consumption of khat significantly reduces semen volume (standardized mean difference = -0.903, 95% CI: -1.801 to -0.007, p = 0.048). In conclusion, our study show that significant associations with LBW, congenital anomalies, and reduced semen volume underscores the necessity for additional research to delve deeper into the intricate complexities of how khat affects reproductive health in both women and men.

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使用阿拉伯茶（Catha edulis）对泌尿生殖系统的影响：系统回顾和荟萃分析。

本研究旨在对有关阿拉伯茶对生殖系统潜在影响的现有文献进行荟萃分析。研究人员检索了五个国际数据库：Embase、Medline/PubMed、Scopus、Web of Knowledge (ISI) 和 ProQuest，检索时间从开始到 2024 年 1 月底。乔安娜-布里格斯研究所（Joanna Briggs Institute，JBI）的 "批判性评估检查表 "用于对纳入研究进行质量评估。经过多个筛选阶段后，10 篇文章被纳入最终分析。汇总荟萃分析结果显示，与不使用卡塔叶的妇女相比，孕期使用卡塔叶的妇女出现低出生体重（LBW）（OR= 2.51，95% CI：1.61-3.95，p 值<0.001）和先天性畸形（OR= 3.17，95% CI：1.31-7.73，p 值=0.011）的几率明显较高。荟萃分析的结果表明，食用阿拉伯茶会显著减少精液量（标准化平均差=-0.903，95% CI：-1.801 至-0.007，p = 0.048）。总之，我们的研究表明，阿拉伯茶与低体重儿、先天性畸形和精液量减少有明显的关联，这突出表明有必要开展更多的研究，以深入探讨阿拉伯茶如何影响男女生殖健康这一错综复杂的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Ethnicity in Substance Abuse SUBSTANCE ABUSE-

CiteScore

3.20

自引率

7.70%

发文量

期刊介绍： The Journal of Ethnicity in Substance Abuse presents rigorous new studies and research on ethnicity and cultural variation in alcohol, tobacco, licit and illicit forms of substance use and abuse. The research is drawn from many disciplines and interdisciplinary areas in the social and behavioral sciences, public health, and helping professions. The Journal of Ethnicity in Substance Abuse is an international forum for identification of emergent and culturally diverse substance use and abuse trends, and the implementation of culturally competent strategies in harm reduction, individual, group, and family treatment of substance abuse. The Journal systematically investigates the beliefs, attitudes, and values of substance abusers, searching for the answers to the origins of drug use and abuse for different ethnic groups. The Journal publishes research papers, review papers, policy commentaries, and conference proceedings. The Journal welcomes submissions from across the globe, and strives to ensure efficient review and publication outcomes.