Health-related quality of life in older hematological cancer survivors (70+) compared to older general population—A German cancer-register-based cross-sectional comparative study

IF 2.3 3区医学 Q2 HEMATOLOGY

European Journal of Haematology Pub Date : 2024-08-01 DOI:10.1111/ejh.14285

Florian Schatz, Anja Mehnert-Theuerkauf, Uwe Platzbecker, Franziska Springer, Heide Götze

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引用次数: 0

Abstract

Objectives

The extent of health-related quality of life (HRQOL) impairments in older hematological cancer survivors (HCS) has not been sufficiently studied. We therefore examined HRQOL in older HCS compared to a community sample (CS) and investigated sociodemographic, disease- and treatment-specific, geriatric, and psychosocial factors associated with reduced HRQOL.

Materials and Methods

In this cancer-register-based cross-sectional comparative study 200 HCS, aged ≥70 years, and 252 persons of an age- and gender-matched CS completed validated questionnaires including the EORTC QLQ-C30 and EORTC QLQ-ELD14.

Results

Older HCS reported a reduced HRQOL in the dimensions of global QOL, physical, role, and social functioning (small clinical significance) and higher symptom burden of fatigue, nausea and vomiting, appetite loss, and poorer mobility compared to the CS (fatigue and mobility with medium, the others with small clinical significance). Perceived disease burden of comorbidities, functional disabilities, psychological distress, and depression showed statistical significance for reduced HRQOL in older HCS in multiple linear regression analysis (R² = .602, p < .001).

Discussion

The screening and treatment of functional limitations and individual symptoms and the integration of a geriatric assessment into oncological practice can help to identify supportive care needs, to implement individualized, patient-centered cancer survivorship care programs and to improve older HCS's HRQOL.

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老年血液肿瘤幸存者（70 岁以上）与老年普通人群相比的健康相关生活质量--基于德国癌症登记的横断面比较研究。

目的：关于老年血液肿瘤幸存者（HCS）健康相关生活质量（HRQOL）受损程度的研究还不够充分。因此，我们将老年血液肿瘤幸存者的健康相关生活质量与社区样本（CS）进行了比较研究，并调查了与健康相关生活质量下降相关的社会人口学、疾病和治疗特异性、老年医学和社会心理因素：在这项以癌症登记为基础的横断面比较研究中，200 名年龄≥70 岁的高危人群和 252 名年龄与性别匹配的社区样本完成了有效问卷，包括 EORTC QLQ-C30 和 EORTC QLQ-ELD14：结果：与 CS 相比，老年 HCS 在总体 QOL、身体、角色和社会功能方面的 HRQOL 下降（临床意义较小），疲劳、恶心和呕吐、食欲不振以及行动不便等症状负担较重（疲劳和行动不便为中度，其他为轻度）。在多元线性回归分析中，合并症、功能障碍、心理困扰和抑郁等感知疾病负担对老年 HCS 的 HRQOL 降低具有统计学意义（R2 = .602，P 讨论）：对功能障碍和个体症状进行筛查和治疗，并将老年病学评估纳入肿瘤治疗实践，有助于确定支持性护理需求，实施个性化的、以患者为中心的癌症幸存者护理计划，并改善老年高危人群的 HRQOL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Haematology 医学-血液学

CiteScore

5.50

自引率

0.00%

发文量

168

审稿时长

4-8 weeks

期刊介绍： European Journal of Haematology is an international journal for communication of basic and clinical research in haematology. The journal welcomes manuscripts on molecular, cellular and clinical research on diseases of the blood, vascular and lymphatic tissue, and on basic molecular and cellular research related to normal development and function of the blood, vascular and lymphatic tissue. The journal also welcomes reviews on clinical haematology and basic research, case reports, and clinical pictures.