Younghoon Kwon, William S Tzeng, Jiwon Seo, Jeongok Gang Logan, Marijana Tadic, Gen-Min Lin, Miguel Angel Martinez-Garcia, Martino Pengo, Xiaoyue Liu, Yeilim Cho, Luciano F Drager, William Healy, Geu-Ru Hong
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引用次数: 0
Abstract
Obstructive sleep apnea (OSA) and hypertension are two important modifiable risk factors for cardiovascular disease and mortality. Numerous studies have highlighted the interplay between these two conditions. We provide a critical review of the current literature on the role of the OSA as a risk factor for hypertension and its effect on blood pressure (BP). We discuss several key topics: the effect of OSA on nocturnal BP, BP response to continuous positive airway pressure (CPAP) treatment, CPAP effect on BP in refractory hypertension, the role of OSA in BP variability (BPV), and maladaptive cardiac remodeling mediated by OSA's effect on BP. Finally, we discuss the unique aspects of ethnicity and social determinants of health on OSA with a focus on Asian populations and the disparity in BP control and cardiovascular outcomes.
阻塞性睡眠呼吸暂停（OSA）和高血压是导致心血管疾病和死亡率的两个重要的可改变风险因素。大量研究强调了这两种疾病之间的相互作用。我们对当前有关 OSA 作为高血压风险因素的作用及其对血压（BP）影响的文献进行了批判性综述。我们讨论了几个关键主题：OSA 对夜间血压的影响、血压对持续气道正压（CPAP）治疗的反应、CPAP 对难治性高血压患者血压的影响、OSA 在血压变异性（BPV）中的作用以及 OSA 对血压的影响所介导的不良心脏重塑。最后，我们讨论了种族和社会健康决定因素对 OSA 的独特影响，重点是亚裔人群以及血压控制和心血管结果的差异。
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