A biologically multifunctional PDA-LYS composite coating is fabricated on the surface of magnesium alloy vascular stents to promote endothelialization

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Journal of Materials Research Pub Date : 2024-07-31 DOI:10.1557/s43578-024-01386-6

Yi Ma, Hao-Jie Guo, Jing-An Li, Yan-Chao Wang, Yi-Fan Zhou

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Abstract

Due to their excellent mechanical properties and biodegradability, biodegradable magnesium alloy vascular stents have become a hot topic in current research on vascular stent material. However, the further application of magnesium alloy is limited by its rapid degradation rate and insufficient ability to promote surface endothelialization. This study proposed a strategy of co-depositing a PDA-LYS coating on the surface of magnesium alloy treated with an alkaline pre-heating process. Experimental results demonstrated that the PDA-LYS composite coating significantly improved the corrosion resistance of the magnesium alloy. Furthermore, with the increase in LYS content in the samples, the coating facilitated the adhesion and proliferation of endothelial cells and effectively inhibited the excessive proliferation of pathological smooth muscle cells. In summary, the PDA-LYS composite coating had a positive impact on the biocompatibility of magnesium alloy, which has offered a new approach for surface modification of magnesium alloy vascular materials.

Graphical abstract

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在镁合金血管支架表面制作生物多功能 PDA-LYS 复合涂层以促进内皮化

可生物降解镁合金血管支架具有优异的机械性能和生物降解性，已成为当前血管支架材料研究的热点。然而，由于镁合金降解速度快，促进表面内皮化的能力不足，其进一步应用受到了限制。本研究提出了在经碱性预热工艺处理的镁合金表面共沉积 PDA-LYS 涂层的策略。实验结果表明，PDA-LYS 复合涂层显著提高了镁合金的耐腐蚀性。此外，随着样品中 LYS 含量的增加，涂层促进了内皮细胞的粘附和增殖，并有效抑制了病理性平滑肌细胞的过度增殖。总之，PDA-LYS 复合涂层对镁合金的生物相容性产生了积极影响，为镁合金血管材料的表面改性提供了一种新方法。

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来源期刊

Journal of Materials Research 工程技术-材料科学：综合

CiteScore

4.50

自引率

3.70%

发文量

362

审稿时长

2.8 months

期刊介绍： Journal of Materials Research (JMR) publishes the latest advances about the creation of new materials and materials with novel functionalities, fundamental understanding of processes that control the response of materials, and development of materials with significant performance improvements relative to state of the art materials. JMR welcomes papers that highlight novel processing techniques, the application and development of new analytical tools, and interpretation of fundamental materials science to achieve enhanced materials properties and uses. Materials research papers in the following topical areas are welcome. • Novel materials discovery • Electronic, photonic and magnetic materials • Energy Conversion and storage materials • New thermal and structural materials • Soft materials • Biomaterials and related topics • Nanoscale science and technology • Advances in materials characterization methods and techniques • Computational materials science, modeling and theory