Regional heterogeneity in the membrane properties of mouse striatal neurons

IF 4.2 3区 医学 Q2 NEUROSCIENCES
Nao Chuhma, Stephen Rayport
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Abstract

The cytoarchitecture of the striatum is remarkably homogeneous, in contrast to the regional variation in striatal functions. Whether differences in the intrinsic membrane properties of striatal neurons contribute to regional heterogeneity has not been addressed systematically. We made recordings throughout the young adult mouse striatum under identical conditions, with synaptic input blocked, from four major striatal neuron types, namely, the two subtypes of spiny projection neurons (SPNs), cholinergic interneurons (ChIs), and fast-spiking GABAergic interneurons (FSIs), sampling at least 100 cells per cell type. Regional variation manifested across all cell types. All cell types in the nucleus accumbens (NAc) shell had higher input impedance and increased excitability. Cells in the NAc core were differentiated from the caudate-putamen (CPu) for both SPN subtypes by smaller action potentials and increased excitability. Similarity between the two SPN subtypes showed regional variation, differing more in the NAc than in the CPu. So, in the Str, both the intrinsic properties of interneurons and projection neurons are regionally heterogeneous, with the greatest difference between the NAc and CPu; greater excitability of NAc shell neurons may make the region more susceptible to activity-dependent plasticity.
小鼠纹状体神经元膜特性的区域异质性
纹状体的细胞结构非常均匀,这与纹状体功能的区域差异形成鲜明对比。纹状体神经元内在膜特性的差异是否导致了区域异质性,目前还没有系统的研究。我们在相同的条件下,在突触输入被阻断的情况下,对整个年轻成年小鼠纹状体的四种主要纹状体神经元类型进行了记录,这四种神经元类型是棘突投射神经元(SPN)的两种亚型、胆碱能中间神经元(ChIs)和快速尖峰 GABA 能中间神经元(FSIs),每种细胞类型至少取样 100 个细胞。所有细胞类型都存在区域差异。所有位于伏隔核(NAc)外壳的细胞类型都具有更高的输入阻抗和更高的兴奋性。对于两种 SPN 亚型而言,NAc 核心的细胞与尾状突起(CPu)的区别在于动作电位更小,兴奋性更高。两种 SPN 亚型之间的相似性表现出区域差异,在 NAc 的差异大于在 CPu 的差异。因此,在Str中,中间神经元和投射神经元的固有特性具有区域异质性,其中NAc和CPu之间的差异最大;NAc壳神经元的更高兴奋性可能使该区域更容易受到活动依赖性可塑性的影响。
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来源期刊
CiteScore
7.90
自引率
3.80%
发文量
627
审稿时长
6-12 weeks
期刊介绍: Frontiers in Cellular Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species. Specialty Chief Editors Egidio D‘Angelo at the University of Pavia and Christian Hansel at the University of Chicago are supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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