‍Mesoporous L-Phenylalanine-CuO as an Eco-Friendly and Efficient Nanocatalyst for 1,2,3-Triazoles Synthesis and Study of Their Antimicrobial Properties

Abstract

A green mesoporous catalyst was prepared by copper immobilization onto L-phenylalanine (L-Phe), and it was studied using different analytical methods, including FT-IR, XRD, FE-SEM, EDX, BET, TGA, DSC, and ICP analysis. Using sodium azide, phenylacetylene, benzyl or alkyl halides, and a nanocatalyst, the CuAAC reaction has been effectively utilized to produce 1,2,3-triazoles with regioselective efficiency. The main advantages of the current approach are the easy recyclability of the catalyst, short reaction time, low cost, simple preparation, and high yield. Furthermore, the (L-Phe)-CuO showed antimicrobial properties.