The relationship between ACE gene insertion/deletion polymorphism and diabetes retinopathy patients with diabetes type 1

IF 0.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

International Journal of Diabetes in Developing Countries Pub Date : 2024-07-29 DOI:10.1007/s13410-024-01378-6

Hifsa Zafar, Imran Riaz Malik, Hafsa Bushra, Khurshid Alam, Muhammad Shakeel, Iftikhar Ahmed, Hadia Gul, Mohamed Farouk Elsadek, Khalid S. Al-Numair, Naveed Ahmad, Muhammad Yasin

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引用次数: 0

Abstract

Background

Diabetes type 1 is an autoimmune metabolic disorder in which auto antibodies attack pancreatic β cells, results in hyperglycemia. Diabetes retinopathy linked to diabetes mellitus that affects blood vessels in the retina results in blindness and visual disability in hyperglycemic people. The angiotensin-I converting has a role in diabetes retinopathy.

Objective

We investigate the relationship between angiotensin-converting enzyme gene insertion/deletion (I/D) polymorphism, diabetes retinopathy patients, and diabetes type 1.

Methods

A total of 250 individuals, including retinopathy patients (100), diabetes type 1 patient (100), and controls (50), were studied. Genomic DNA was extract from blood samples and PCR was used to detect the ACE polymorphism by using primers. The obtained data was statistically analyzed through SPSS.

Results

The prevalence of D and I alleles in diabetes retinopathy patients was 57.5% and 42.5%, respectively; in diabetes type 1, it was 66% and 34%, respectively; and in control subjects, it was 69% and 31%, respectively. This study showed the prevalence of the DD genotype and D allele in all groups under study. However, ACE gene polymorphisms may not have much influence on the progression of diabetes retinopathy.

Conclusion

It was established that those with diabetes retinopathy frequently have the angiotensin-converting enzyme gene I/D polymorphism.

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ACE基因插入/缺失多态性与1型糖尿病患者视网膜病变的关系

背景1型糖尿病是一种自身免疫性代谢紊乱，自身抗体攻击胰腺β细胞，导致高血糖。糖尿病视网膜病变与糖尿病有关，影响视网膜血管，导致高血糖患者失明和视力残疾。目的我们研究了血管紧张素转换酶基因插入/缺失（I/D）多态性与糖尿病视网膜病变患者和糖尿病 1 型之间的关系。方法共研究了 250 人，包括视网膜病变患者（100 人）、糖尿病 1 型患者（100 人）和对照组（50 人）。从血液样本中提取基因组 DNA，使用引物进行 PCR 检测 ACE 多态性。结果糖尿病视网膜病变患者中 D 型和 I 型等位基因的患病率分别为 57.5%和 42.5%；1 型糖尿病患者中 D 型和 I 型等位基因的患病率分别为 66%和 34%；对照组中 D 型和 I 型等位基因的患病率分别为 69%和 31%。这项研究显示，DD 基因型和 D 等位基因在所有研究群体中都很普遍。结论研究发现，糖尿病视网膜病变患者中，血管紧张素转换酶基因 I/D 多态性的发生率较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Diabetes in Developing Countries ENDOCRINOLOGY & METABOLISM-

CiteScore

1.60

自引率

0.00%

发文量

109

审稿时长

6 months

期刊介绍： International Journal of Diabetes in Developing Countries is the official journal of Research Society for the Study of Diabetes in India. This is a peer reviewed journal and targets a readership consisting of clinicians, research workers, paramedical personnel, nutritionists and health care personnel working in the field of diabetes. Original research articles focusing on clinical and patient care issues including newer therapies and technologies as well as basic science issues in this field are considered for publication in the journal. Systematic reviews of interest to the above group of readers are also accepted.