Bone marrow niches for hematopoietic stem cells

IF 7.6 2区 医学 Q1 HEMATOLOGY
HemaSphere Pub Date : 2024-07-31 DOI:10.1002/hem3.133
Ana Luísa Pereira, Serena Galli, César Nombela-Arrieta
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引用次数: 0

Abstract

Hematopoietic stem cells (HSCs) are the cornerstone of the hematopoietic system. HSCs sustain the continuous generation of mature blood derivatives while self-renewing to preserve a relatively constant pool of progenitors throughout life. Yet, long-term maintenance of functional HSCs exclusively takes place in association with their native tissue microenvironment of the bone marrow (BM). HSCs have been long proposed to reside in fixed and identifiable anatomical units found in the complex BM tissue landscape, which control their identity and fate in a deterministic manner. In the last decades, tremendous progress has been made in the dissection of the cellular and molecular fabric of the BM, the structural organization governing tissue function, and the plethora of interactions established by HSCs. Nonetheless, a holistic model of the mechanisms controlling HSC regulation in their niche is lacking to date. Here, we provide an overview of our current understanding of BM anatomy, HSC localization, and crosstalk within local cellular neighborhoods in murine and human tissues, and highlight fundamental open questions on how HSCs functionally integrate in the BM microenvironment.

Abstract Image

造血干细胞的骨髓龛位。
造血干细胞是造血系统的基石。造血干细胞可持续生成成熟的血液衍生物,同时进行自我更新,在整个生命过程中保持相对恒定的祖细胞池。然而,功能性造血干细胞的长期维持只能与其骨髓(BM)的原生组织微环境相关联。长期以来,人们一直认为造血干细胞居住在复杂的骨髓组织景观中固定且可识别的解剖单元中,这些单元以确定性的方式控制着造血干细胞的身份和命运。在过去几十年中,人们在剖析 BM 的细胞和分子结构、支配组织功能的结构组织以及造血干细胞建立的大量相互作用方面取得了巨大进展。然而,迄今为止还缺乏一个关于造血干细胞在其生态位中调控机制的整体模型。在此,我们将概述目前我们对基底膜解剖、造血干细胞定位以及小鼠和人体组织中局部细胞邻域内相互协作的理解,并强调造血干细胞如何在基底膜微环境中发挥整合功能的基本开放性问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
HemaSphere
HemaSphere Medicine-Hematology
CiteScore
6.10
自引率
4.50%
发文量
2776
审稿时长
7 weeks
期刊介绍: HemaSphere, as a publication, is dedicated to disseminating the outcomes of profoundly pertinent basic, translational, and clinical research endeavors within the field of hematology. The journal actively seeks robust studies that unveil novel discoveries with significant ramifications for hematology. In addition to original research, HemaSphere features review articles and guideline articles that furnish lucid synopses and discussions of emerging developments, along with recommendations for patient care. Positioned as the foremost resource in hematology, HemaSphere augments its offerings with specialized sections like HemaTopics and HemaPolicy. These segments engender insightful dialogues covering a spectrum of hematology-related topics, including digestible summaries of pivotal articles, updates on new therapies, deliberations on European policy matters, and other noteworthy news items within the field. Steering the course of HemaSphere are Editor in Chief Jan Cools and Deputy Editor in Chief Claire Harrison, alongside the guidance of an esteemed Editorial Board comprising international luminaries in both research and clinical realms, each representing diverse areas of hematologic expertise.
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