Volumetric analysis of pons, middle brain and thalamus by MRI in migraine patients; and evaluation of vertebral artery diameter

M. Şahan, N. Muluk, Fatih Kocturk, Melih Akşamoğlu
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Abstract

OBJECTIVES. We investigated whether there were atrophic changes in grey matter (pons, midbrain, and thalamus) in migraine patients. Vertebral artery diameters were also evaluated. MATERIAL AND METHODS. The cranial MRI images of 49 adult migraine-diagnosed patients and 49 adult subjects with normal cranial MRI results were included in the study. In both groups, pons, midbrain, and thalamus volumes, as well as vertebral artery diameters were measured. RESULTS. There were no significant differences between pons, midbrain, bilateral thalamus volumes and vertebral artery diameters of the migraine and control groups (p>0.05). In the right-sided migraine group, the right thalamus volume was significantly lower than the contralateral side (p<0.05). In the left-sided migraine group, the left thalamus volume was non-significantly lower than the contra-lateral side (p>0.05). In the right-sided and left-sided migraine groups, left vertebral artery diameters were significantly higher than those on the right side (p<0.05). In older migraine patients, pons and midbrain volumes decreased (p<0.05). In longer migraine duration, pons volume decreased (p<0.05). In aura-present migraine patients, right vertebral artery diameters decreased (p<0.05). CONCLUSION. We concluded that migraine is related to grey matter atrophy in terms of thalamus atrophy on the migraine side. Pons atrophy in longer migraine, and pons and midbrain atrophy in older migraine patients were also detected. Therefore, during the follow-up of the migraine patients, grey matter atrophy should be examined by MRI, and treatment to prevent migraine attacks should be planned.
通过核磁共振成像分析偏头痛患者脑桥、中脑和丘脑的体积;评估椎动脉直径
目的:我们研究了偏头痛患者的灰质(脑桥、中脑和丘脑)是否发生萎缩性变化。我们研究了偏头痛患者的灰质(脑桥、中脑和丘脑)是否存在萎缩性变化。同时还对椎动脉直径进行了评估。 研究对象包括 49 名确诊为偏头痛的成年患者和 49 名头颅磁共振成像结果正常的成年受试者。对两组患者的脑桥、中脑和丘脑体积以及椎动脉直径进行了测量。 结果偏头痛组和对照组的桥脑、中脑、双侧丘脑体积和椎动脉直径无明显差异(P>0.05)。在右侧偏头痛组中,右侧丘脑体积明显低于对侧(P0.05)。在右侧和左侧偏头痛组中,左侧椎动脉直径明显高于右侧(P<0.05)。在年龄较大的偏头痛患者中,脑桥和中脑体积缩小(P<0.05)。偏头痛持续时间越长,脑桥体积越小(P<0.05)。在有先兆的偏头痛患者中,右侧椎动脉直径减小(P<0.05)。 结论。我们得出结论,偏头痛与灰质萎缩有关,偏头痛一侧丘脑萎缩。此外,还发现偏头痛病程较长的患者脑桥萎缩,偏头痛病程较长的患者脑桥和中脑萎缩。因此,在对偏头痛患者进行随访时,应通过核磁共振成像检查灰质萎缩情况,并制定预防偏头痛发作的治疗方案。
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