Tissue plasminogen activator associated pulmonary hemorrhage in patient with ACTA2-associated arteriopathy

IF 0.7 Q4 SURGERY

Journal of Vascular Surgery Cases Innovations and Techniques Pub Date : 2024-07-27 DOI:10.1016/j.jvscit.2024.101558

Travis G. Hughes MD , Mark A. Wurth MD, PhD , Mary B. Sheppard MD

引用次数: 0

Abstract

Pulmonary hemorrhage after administration of tissue plasminogen activator (tPA) is a rare complication. We present a 15-year-old boy with a heterozygous pathogenic variant in ACTA2 who presented with right brachial artery aneurysm thrombosis treated initially with tPA, resulting in pulmonary hemorrhage. We hypothesize that the underlying pulmonary abnormalities caused by the pathogenic ACTA2 variant may be a risk factor for pulmonary hemorrhage after tPA administration.

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ACTA2 相关动脉病变患者与组织浆细胞蛋白酶原激活剂相关的肺出血

使用组织纤溶酶原激活剂（tPA）后出现肺出血是一种罕见的并发症。我们报告了一名患有 ACTA2 杂合子致病变异体的 15 岁男孩，他因右肱动脉瘤血栓形成接受了 tPA 治疗，结果导致肺出血。我们推测，ACTA2致病变异体引起的潜在肺部异常可能是导致服用tPA后肺出血的一个危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vascular Surgery Cases Innovations and Techniques SURGERY-

CiteScore

1.00

自引率

14.30%

发文量

219

审稿时长

29 weeks

期刊介绍： Journal of Vascular Surgery Cases and Innovative Techniques is a surgical journal dedicated to publishing peer review high quality case reports, vascular images and innovative techniques related to all aspects of arterial, venous, and lymphatic diseases and disorders, including vascular trauma, malformations, wound care and the placement and maintenance of arterio-venous dialysis accesses with an emphasis on the practicing clinician. The Journal seeks to provide novel and timely information to vascular surgeons, interventionalists, phlebologists, wound care specialists, and allied health professionals involved with the management of patients with the entire spectrum of vascular disorders.