Therapeutic aspects of mesenchymal stems cells in medulloblastoma therapy: A review of the current knowledge: MSCs for Medulloblastoma

Abstract

Medulloblastoma (MB), the most common malignant brain tumor in children, presents a significant therapeutic challenge. Despite advancements in treatment regimens, particularly for recurrence and leptomeningeal spread, achieving long-term survival for MB patients remains elusive. Multimodal therapies, including radiation, chemotherapy, and extensive surgical, have improved survival rates; however, roughly one-third of patients still face an incurable disease. Integrating mesenchymal stem cells (MSCs) from various sources is increasingly explored in novel therapeutic strategies. Hence, this review aims to comprehensively examine the migratory potential and therapeutic efficacy of MSCs in the context of experimental MB models. While MSCs are emerging as innovative cell-based delivery vehicles, their specific therapeutic potential in MB treatment requires further investigation.