Cytological Grading of Breast Carcinoma and Its Correlation with Histological Grading

Abstract

Background. Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma death in women. Since the easiest way of diagnosing breast carcinoma is Fine Needle Aspiration Cytology (FNAC), it is important to perform grading of the malignancy on aspirates obtained as it will provide valuable information for further management. Materials and Methods. It is a hospital-based prospective study conducted in the Department of Pathology (Cytopathology and Histopathology) at B.P. Koirala Institute of Health Sciences, Dharan, Nepal for one year, including forty-five (45) cases. Results. ost patients were in the age group 41–50 years. The most common type of carcinoma detected was an Infiltrating ductal carcinoma followed by Infiltrating lobular carcinoma. The correlation between cytopathology and histopathology findings was evaluated by utilizing the Simplified Black grading Modified Black grading, Hunt’s grading, and Nottingham Modification of Scarff-Bloom-Richardson grading system all of then showed more than 80% concordance rate. Conclusion. Grading of breast malignancy obtained from Fine Needle Aspiration Cytology smears is easy to perform and has a high concordance rate with histological grading.