Trihexyphenidyl has a psychostimulant-like effect on mice

Zeina A.Althanoon, Loay A. Alchalaby, Farah Ramzi, Marwan M. Merkhan
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引用次数: 0

Abstract

Trihexyphenidyl is an antimuscarinic agent used for managing motor symptoms in Parkinson’s disease (PD). Despite its therapeutic use, trihexyphenidyl misuse and addiction have been reported. Its antimus¬carinic effect alone does not explain this abuse potential. This study investigated if trihexyphenidyl pro¬duces psychostimulant-like behavioural effects in mice related to dopamine signalling. Male and female mice received 1 or 2 mg/kg trihexyphenidyl orally before open field and forced swim tests. Trihex¬yphenidyl at 2 mg/kg increased locomotor activity, prevented by olanzapine pre-treatment. It also de¬creased forced swim test immobility time. These findings suggest trihexyphenidyl has dopamine-medi¬ated psycho-stimulant properties, providing preclinical evidence for its abuse liability. Further studies on trihexyphenidyl’s impact on dopamine neurotransmission and addiction risk are warranted.
三苯氧胺对小鼠具有类似精神兴奋剂的作用
三苯氧胺是一种抗心绞痛药,用于控制帕金森病(PD)的运动症状。尽管三苯氧胺具有治疗作用,但也有滥用和成瘾的报道。仅凭三苯氧胺的抗心律失常作用并不能解释其滥用的可能性。本研究调查了三苯氧胺是否会对小鼠产生与多巴胺信号有关的精神兴奋剂样行为效应。雄性和雌性小鼠在进行开阔地和强迫游泳测试前,分别口服1或2毫克/千克三苯氧胺。2毫克/千克的三苯氧胺会增加小鼠的运动能力,而奥氮平的预处理可以阻止这种现象。它还能缩短强迫游泳测试的静止时间。这些研究结果表明,三苯氧胺具有多巴胺介导的精神兴奋剂特性,为其滥用提供了临床前证据。有关三苯氧胺对多巴胺神经递质的影响和成瘾风险的进一步研究还很有必要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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