The Influence of the Cooperation of Hyperhomocysteinemia and Arterial Hypertension. A Risk Factor on the Acceleration of the Progress of Chronic Renal Diseases

Abstract

Introduction: Chronic kidney disease (CKD) is a heterogeneous group of disorders that manifest differently with a multifactorial etiology. In addition to known factors such as diabetes, high blood pressure, genetic predisposition, age, gender, race, physical inactivity, obesity, and MIA, in recent years, high concentrations of homocysteine have also been considered as an independent risk factor in the acceleration of the progression of CKD, which, together with arterial hypertension, apparently affect the acceleration of the progress of chronic renal diseases. Materials and Methods: In a cohort-prospective study, 100 patients were treated (40 women with an average age of 55.40±8.20 years and 60 men with an average age of 56.00±9.50 years) with CKD in the third stage (stage   III   and b   b) with a GFR of 30- 59 ml/min/ 1.73m2 determined according to the formula modification of diet in renal disease (MDRD- GFR in ml/min for 1.73 m2=175 x Serum creatinine (Cr)  -1.154 x age-0.203x1.212 (if the patient is black) x 0.742 (if female) treated in the internal medicine clinic at the Clinical Hospital in Tetovo, in the period January-2023-December-2023 randomized according to gender, age, nationality, primary kidney disease… Results: The results obtained at the beginning of the study for all the examined parameters and those obtained after 12 months, both from the patients with Chronic disease and the control group of healthy individuals, are presented in the text below. A significant difference was observed between the patients and the control group with p<0.0001. Conclusion: CKD is a frequent occurrence worldwide (1 in 10 inhabitants or 10 of the world's population suffers from CKD; therefore, it is necessary to implement preventive and therapeutic measures aimed at early detection, prevention, and treatment of that disease as a conclusion of our paper, we can confirm that there is a strong connection between HHcy and high blood pressure and that together they contribute to the acceleration and progression of CKD; therefore their treatment with folate, vitamin B12, vitamin B6 should be started at an early stage of the disease to prevent the rapid progression of CKD.