Effect of Swimming Exercise on Levels of Blood Glucose, Adiponectin, Glucose-6-Phosphatase and Lipid Profile in Diabetic Wistar Rats

Advances in Applied Physiology Pub Date : 2024-07-23 DOI:10.11648/j.aap.20240901.12

Isehunwa Olufunmilayo, Layonu Mojirade

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Abstract

Diabetes mellitus is a chronic metabolic condition that causes persistent hyperglycemia due to insulin action or secretion. Regular physical exercise has been reported to improve glycemia and lipid profile in diabetes. However, literature is scare on the effects of swimming exercise on the serum levels of adiponectin and glucose 6 phosphatase in Wister rats with diabetes This study therefore, investigated the effects of swimming exercise on adiponectin, glucose 6-phosphatase and lipid profile in male Wistar rats with streptozotocin-induced diabetes. This study was carried out on 25 male Wistar rats grouped into five groups (n=5/group): group 1=control, group 2=diabetes, group 3=diabetes treated with metformin, group 4=non-diabetes and swimming exercise, group 5=diabetes and swimming exercise. Animals in groups 2, 3, and 5 were induced with Streptozotocin (STZ) 50 mg/kg intraperitoneally. After 72 hours of diabetes induction, animals with a blood glucose level of ≥ 200 mg/dl were confirmed diabetics and used for the study. Group 3 animals were treated with metformin 200mg/kg giving orally for 28 days. Animals in groups 4 and 5 were subjected to swimming exercises for 5-10 minutes during the first week until they could swim freely for 30 minutes. The animals were then allowed to swim 5 days per week for 28 days. Swimming exercise for 28 days significantly reduced blood glucose, glucose-6-phosphatase (G6Ppase), Lactate dehydrogenase (LDH), Total cholesterol (TC), and Low-density lipoprotein (LDL) levels but caused significant increase in adiponectin and High-density lipoprotein (HDL) levels in diabetic rats compared with untreated diabetic rats. There was a significant decrease in triglyceride (TG) of diabetic animals caused by swimming for 28 days. This study demonstrated that swimming exercise for 28 days may help lower glucose level and improve insulin sensitivity by increasing adiponectin level and decreasing G6Pase activity in diabetic rats. Also, swimming exercise may help improve lipid profile in diabetic rats.

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游泳运动对糖尿病 Wistar 大鼠血糖、脂肪连接蛋白、葡萄糖-6-磷酸酶和血脂水平的影响

糖尿病是一种慢性代谢疾病，由于胰岛素的作用或分泌而导致持续性高血糖。据报道，经常进行体育锻炼可改善糖尿病患者的血糖和血脂状况。然而，有关游泳运动对糖尿病 Wistar 雄性大鼠血清中脂联素及葡萄糖 6-磷酸酶水平影响的文献却很少。这项研究以 25 只雄性 Wistar 大鼠为对象，分为五组（n=5/组）：第 1 组=对照组，第 2 组=糖尿病组，第 3 组=二甲双胍治疗糖尿病组，第 4 组=非糖尿病和游泳运动组，第 5 组=糖尿病和游泳运动组。第 2、3 和 5 组的动物腹腔注射链脲佐菌素（STZ）50 毫克/千克。糖尿病诱导 72 小时后，血糖水平≥ 200 mg/dl 的动物被确认为糖尿病患者并用于研究。第 3 组动物连续 28 天口服二甲双胍 200 毫克/千克。第 4 组和第 5 组动物在第一周接受 5-10 分钟的游泳训练，直到它们可以自由游泳 30 分钟。然后让动物每周游泳 5 天，共 28 天。与未经治疗的糖尿病大鼠相比，连续 28 天的游泳运动能显著降低糖尿病大鼠的血糖、葡萄糖-6-磷酸酶（G6Ppase）、乳酸脱氢酶（LDH）、总胆固醇（TC）和低密度脂蛋白（LDL）水平，但能显著增加脂肪连通素和高密度脂蛋白（HDL）水平。游泳 28 天后，糖尿病动物的甘油三酯（TG）明显下降。这项研究表明，持续 28 天的游泳运动可通过提高糖尿病大鼠的脂肪连接蛋白水平和降低 G6Pase 活性，帮助降低血糖水平和改善胰岛素敏感性。此外，游泳运动还有助于改善糖尿病大鼠的血脂状况。

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Advances in Applied Physiology

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