The crosstalk between N6-methyladenosine readers and neuroblastoma

Clinical and translational discovery Pub Date : 2024-07-23 DOI:10.1002/ctd2.344

Liping Chen, Jing He, Zhenjian Zhuo

{"title":"The crosstalk between N6-methyladenosine readers and neuroblastoma","authors":"Liping Chen, Jing He, Zhenjian Zhuo","doi":"10.1002/ctd2.344","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Neuroblastoma (NB) is a heterogeneous pediatric solid tumour strongly influenced by epigenetic modifications.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This review explores the role of N6-methyladenosine (m6A) modifications and their readers in NB progression.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Dysregulation of m6A readers, including YTHDF1/2, YTHDC1, IGF2BP1/2/3, HNRNPA2B1 and HNRNPC, has been associated with susceptibility and progression.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Understanding the crosstalk between m6A readers and NB could offer new insights into diagnosis, prognosis, and treatment strategies.</p>\n </section>\n </div>","PeriodicalId":72605,"journal":{"name":"Clinical and translational discovery","volume":"4 4","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ctd2.344","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and translational discovery","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ctd2.344","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Neuroblastoma (NB) is a heterogeneous pediatric solid tumour strongly influenced by epigenetic modifications.

Methods

This review explores the role of N6-methyladenosine (m6A) modifications and their readers in NB progression.

Results

Dysregulation of m6A readers, including YTHDF1/2, YTHDC1, IGF2BP1/2/3, HNRNPA2B1 and HNRNPC, has been associated with susceptibility and progression.

Conclusion

Understanding the crosstalk between m6A readers and NB could offer new insights into diagnosis, prognosis, and treatment strategies.

Abstract Image

查看原文本刊更多论文

N6-甲基腺苷阅读器与神经母细胞瘤之间的相互影响

神经母细胞瘤（NB）是一种异质性儿科实体瘤，受表观遗传修饰的影响很大。本综述探讨了N6-甲基腺苷（m6A）修饰及其阅读器在NB进展中的作用。m6A阅读器（包括YTHDF1/2、YTHDC1、IGF2BP1/2/3、HNRNPA2B1和HNRNPC）的失调与NB的易感性和进展有关。了解m6A阅读器与NB之间的相互关系可为诊断、预后和治疗策略提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical and translational discovery

CiteScore

1.00

自引率

0.00%

发文量