Evaluation of therapeutic effectiveness of antituberculosis injection based on conversion time in drug-resistant tuberculosis

Emy Oktaviani, K. Anggadiredja, Lia Amalia
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Abstract

Drug-resistant tuberculosis is a condition in which Mycobacterium tuberculosis is resistant to first-line anti-tuberculosis drugs, namely isoniazid and rifampicin, which are the two most effective anti-tuberculosis agents. Conversion time is a parameter to assess whether the therapeutic effect of injection has been achieved by carrying out two acid-resistant bacilli (ARB) sputum examinations within a maximum period of 2 consecutive months. Kanamycin and capreomycin are injectable drugs that are used in the intensive phase. This cross-sectional study aimed to evaluate the therapeutic effect of injection using ARB sputum conversion time and to analyze other factors related to ARB sputum conversion time. The study used retrospective data from patients’ medical records, collected with purposive sampling technique. The results of the study showed that from 101 patients who met the inclusion criteria 57.4% used kanamycin and 42.6% received capreomycin. The therapeutic effect was achieved in 87.1%. There was no significant correlation between the type of injection therapy and therapeutic effectiveness (p-value = 0.983). In conclusion, therapy using injections for drug-resistant tuberculosis is effective but still requires close monitoring due to the high adverse drug reaction (ADR).
根据抗药性结核病的转化时间评估抗结核注射剂的疗效
耐药性结核病是指结核分枝杆菌对一线抗结核药物(即异烟肼和利福平这两种最有效的抗结核药物)产生耐药性。转化时间是一个参数,通过在最长连续两个月内进行两次耐酸杆菌(ARB)痰液检查来评估注射是否达到治疗效果。卡那霉素和卡曲霉素是强化阶段使用的注射药物。这项横断面研究旨在利用 ARB 痰液转化时间评估注射剂的治疗效果,并分析与 ARB 痰液转化时间相关的其他因素。研究采用了有目的抽样技术,从患者病历中收集了回顾性数据。研究结果显示,在符合纳入标准的 101 名患者中,57.4% 的患者使用了卡那霉素,42.6% 的患者使用了卡格雷霉素。87.1%的患者取得了治疗效果。注射疗法的类型与疗效之间没有明显的相关性(P 值 = 0.983)。总之,使用注射疗法治疗耐药性结核病是有效的,但由于药物不良反应(ADR)较高,仍需密切监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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