B12 deficiency epidemic? Should B12 level lower limit reference values be decreased?

Keramettin Yanık, Atakan Özkan
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Abstract

Background: This study aims to examine B12 levels in general in our society, to determine the rates of B12 deficiency, and to determine and recommend new B12 reference range values according to current data. Methods: A total of 16497 patients who were admitted to our secondary care hospital for various reasons in the three-year period between January 2021 and December 2023 and whose B12 levels were tested in their serum were included in the study. B12 levels of all patients were measured in the hospital biochemistry laboratory on Architect i1000SR and i2000 SR (Abbott diagnostics, Ireland) devices. Results: The reference ranges for B12 levels, determined as 2.5% and 97.5%, were 130-1084 pg/ml for adult men, and as 137-993 pg/ml for adult women. Considering 200 pg/ml as the normal lower limit for B12 level, low levels were found in 14.6% of all patients. Conclusions: Our study is one of the rare studies in which B12 reference ranges are investigated up-to-date with a large patient participation. Our findings showed that the rate of B12 deficiency in the society is very high compared to the generally accepted reference lower limit values, that B12 levels in the society are very low compared to these reference values, and perhaps that the reference lower limit values may need to be reduced to 149-138 pg/ml in individuals under 18 years of age, 130-137 pg/ml in adults, and 123-125 pg/ml in the elderly.
B12 缺乏症流行吗?是否应该降低 B12 水平的下限参考值?
背景:本研究旨在调查社会中 B12 的总体水平,确定 B12 缺乏率,并根据现有数据确定和推荐新的 B12 参考范围值:本研究旨在检测我国社会的总体B12水平,确定B12缺乏率,并根据现有数据确定和推荐新的B12参考范围值:研究对象包括 2021 年 1 月至 2023 年 12 月这三年期间因各种原因入住我院二级医院的 16497 名患者,这些患者的血清中均检测了 B12 含量。所有患者的 B12 含量均在医院生化实验室的 Architect i1000SR 和 i2000 SR(雅培诊断公司,爱尔兰)设备上进行检测:B12水平的参考范围分别为2.5%和97.5%,成年男性为130-1084 pg/ml,成年女性为137-993 pg/ml。如果将 200 pg/ml 作为 B12 水平的正常下限,则所有患者中有 14.6% 的人的 B12 水平偏低:我们的研究是少有的在大量患者参与下对 B12 参考范围进行最新调查的研究之一。我们的研究结果表明,与普遍接受的参考下限值相比,社会中的 B12 缺乏率非常高,与这些参考值相比,社会中的 B12 水平非常低,也许需要将 18 岁以下人群的参考下限值降至 149-138 pg/ml,成年人降至 130-137 pg/ml,老年人降至 123-125 pg/ml。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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