Development of SIMPATEC-USP: An abbreviated impactor for rapid testing of inhalation devices

Gabriel Lima, Barros Araujo, Cleudeucio Manoel Ferreira, Santos Nascimento, Mariana Yasue, Saito Miyagi, Ana Paula, Santos Cardoso, Luiz Henrique, P. Gabriel, Lima
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Abstract

Cascade impactors like the Andersen Cascade Impactor (ACI) and Next Generation Impactor (NGI) are complex and costly due to multiple stages. This study introduces SIMPATEC-USP (Simplified Impactor Developed at the University of São Paulo), a low-cost, single-stage alternative meeting US Pharmacopeia standards for testing dry powder inhalers (DPIs). SIMPATEC-USP simplifies particle retention into a single Petri dish stage, eliminating multi-stage complexity. Its design includes a straightforward closure system for easy assembly/disassembly. A collection chamber holds a glass Petri dish with filter paper for final filtration, ensuring efficient aerosol product collection. SIMPATEC-USP also offers potential use with culture media for applications like antibacterial screening. Operating at 30 L/min, SIMPATEC-USP consists of three parts: a single-stage chamber, an L-shaped tube mimicking the trachea, and a vacuum pump. Aerosol particles are deposited onto the Petri dish via a nozzle, and the collected sample is weighed to determine drug concentration. Tested with inhalation-grade lactose, SIMPATEC-USP effectively collects and analyzes particles, allowing for rapid aerodynamic comparison of formulations, capsule retention assessment, and sample collection for drug release studies. The results demonstrate that it is possible to evaluate the performance of three inhalation devices regarding the mass migrating to the collection plate and that retained within the device itself. In conclusion, SIMPATEC-USP is highly suitable for exploratory studies and educational activities in pharmaceutical technology and pulmonary drug delivery systems.
开发 SIMPATEC-USP:用于快速测试吸入装置的简易冲击器
像安徒生级联冲击器(ACI)和下一代冲击器(NGI)这样的级联冲击器由于有多个阶段,所以非常复杂且成本高昂。本研究介绍了 SIMPATEC-USP(圣保罗大学开发的简化冲击器),这是一种符合美国药典标准的低成本单级替代品,可用于测试干粉吸入器 (DPI)。SIMPATEC-USP 将颗粒截留简化为单个培养皿阶段,消除了多阶段的复杂性。其设计包括一个简单的封闭系统,便于组装/拆卸。收集室可容纳一个玻璃培养皿,其中装有用于最终过滤的滤纸,确保高效收集气溶胶产品。SIMPATEC-USP 还可与培养基一起用于抗菌筛选等应用。SIMPATEC-USP 的运行速度为 30 升/分钟,由三部分组成:单级腔体、模仿气管的 L 形管和真空泵。气溶胶微粒通过喷嘴沉积到培养皿中,收集的样品经称重后测定药物浓度。通过使用吸入级乳糖进行测试,SIMPATEC-USP 能够有效地收集和分析微粒,从而对制剂进行快速空气动力学比较、胶囊保留评估以及收集用于药物释放研究的样品。结果表明,可以评估三种吸入装置的性能,即迁移到收集板的质量和装置本身保留的质量。总之,SIMPATEC-USP 非常适合制药技术和肺部给药系统方面的探索性研究和教育活动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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