Reproductive hormones and sex differences in relation to brachial-ankle pulse wave velocity in obese subjects: a retrospective case-control study.

IF 2.6 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Endocrine Connections Pub Date : 2024-08-19 Print Date: 2024-09-01 DOI:10.1530/EC-24-0190
Yunting Lin, Endi Song, Han Jin, Yong Jin
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引用次数: 0

Abstract

Background: Reproductive hormones may be a risk factor for cardiovascular disease (CVD), but their influence is often underestimated. Obesity can exacerbate the progression of CVD. Arterial stiffness (AS) is correlated with the risk of CVD. Brachial-ankle pulse wave velocity (baPWV) has served as a practical tool for assessing AS with broad clinical applications. This study aimed to investigate the association between reproductive hormones and baPWV in obese male and female subjects.

Methods: A retrospective case-control design was designed. AS was assessed using baPWV, with a baPWV ≥ 1400 cm/s indicating increased AS. Between September 2018 and October 2022, 241 obese subjects with increased AS were recruited from Ningbo Yinzhou No. 2 Hospital. The control group consisted of 241 obese subjects without increased AS. A 1:1 propensity score matching was performed to correct potential confounders by age and sex. We additionally performed a sex-based sub-analysis.

Results: Correlation analysis demonstrated that luteinizing hormone (LH) (r = 0.214, P = 0.001) and follicle-stimulating hormone (FSH) (r = 0.328, P < 0.001) were positively correlated with baPWV in obese male subjects. In the multivariate conditional logistic regression analysis, FSH (OR = 1.407, 95% CI = 1.040-1.902, P = 0.027) rather than LH (OR = 1.210, 95% CI = 0.908-1.612, P = 0.194) was independently and positively associated with increased AS in obese male subjects. However, there was no significant correlation between reproductive hormones and baPWV in women.

Conclusions: Our study identified FSH as a potential risk factor for arteriosclerosis in obese male subjects. This provides a novel and intriguing perspective on the pathogenesis of CVD in obese subjects.

肥胖者生殖激素与肱踝脉搏波速度的性别差异:一项回顾性病例对照研究。
背景:生殖激素可能是心血管疾病(CVD)的风险因素,但其影响往往被低估。肥胖会加剧心血管疾病的恶化。动脉僵化(AS)与心血管疾病的风险相关。肱踝关节脉搏波速度(BaPWV)是评估动脉僵化的实用工具,具有广泛的临床应用价值。本研究旨在调查肥胖男性和女性受试者的生殖激素与肱踝脉搏波速度之间的关系:方法:采用回顾性病例对照设计。使用baPWV评估动脉僵化(AS),baPWV≥1400 cm/s表示AS增加。2018年9月至2022年10月期间,从宁波市鄞州第二医院招募了241名AS增高的肥胖受试者。对照组由 241 名无 AS 增高的肥胖受试者组成。我们进行了1:1倾向得分匹配,以校正年龄和性别的潜在混杂因素。我们还进行了基于性别的子分析:结果:相关性分析表明,促黄体生成素(LH)(r=0.214,P=0.001)和促卵泡激素(FSH)(r=0.328,P=0.001)是影响AS增加的潜在因素:我们的研究发现 FSH 是肥胖男性动脉硬化的潜在风险因素。这为肥胖者心血管疾病的发病机制提供了一个新颖而有趣的视角。
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来源期刊
Endocrine Connections
Endocrine Connections Medicine-Internal Medicine
CiteScore
5.00
自引率
3.40%
发文量
361
审稿时长
6 weeks
期刊介绍: Endocrine Connections publishes original quality research and reviews in all areas of endocrinology, including papers that deal with non-classical tissues as source or targets of hormones and endocrine papers that have relevance to endocrine-related and intersecting disciplines and the wider biomedical community.
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