A novel and convenient method for the synthesis of 1,2,4-oxadiazole-5-thiones

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2024-07-23 DOI:10.1002/jhet.4874

Babak Kaboudin, Saman Soleymanie, Ali Sabzalipour, Foad Kazemi, Haruhiko Fukaya

引用次数: 0

Abstract

A novel and convenient method for the synthesis of 1,2,4-oxadiazole-5-thiones with carbon disulfide as effective C=S source has been developed in a super basic condition. The presented method has a broad substrate scope, and various corresponding 1,2,4-oxadiazole-5-thiones have been obtained in good to excellent yields. This method allows to the gram-scale synthesis of products. Under similar conditions, synthesis of diazole thione benzothioamide derivative from p-cyanobenzamidoxime with CS₂ has been successfully achieved.

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合成 1,2,4-噁二唑-5-硫酮的新颖简便方法

以二硫化碳作为有效的 C=S 源，在超碱性条件下合成 1,2,4-噁二唑-5-硫酮的新颖而简便的方法已经开发出来。所提出的方法具有广泛的底物范围，并以良好到极佳的产率获得了各种相应的 1,2,4-噁二唑-5-硫酮。这种方法可以合成克级规模的产品。在类似条件下，利用 CS2 成功合成了对氰基苯甲脒肟的重氮硫酮硫代苯甲酰胺衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.