Boron-doped diamond electrodes: examining the effect of doping level on the degradation of pharmaceuticals

Monatshefte für Chemie / Chemical Monthly Pub Date : 2024-07-24 DOI:10.1007/s00706-024-03233-0

Lucie Pražáková, Jan Fischer, Andrew Taylor, Anna Kubíčková

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Abstract

The effect of the boron content doped in the diamond electrode on the oxidative degradation behaviour of the active pharmaceutical ingredient abacavir was investigated. The characteristics of five working boron-doped diamond electrodes, differing in a B/C doping ratio of 500 ppm, 1000 ppm, 2000 ppm, 4000 ppm, and 8000 ppm, were studied. The oxidative degradation of the substance abacavir was studied in a batch cell. The degradation took place under potentiostatic electrolysis at potentials from +0.6 V to +3.7 V. The boron level has a significant effect on the oxidative degradation of the substance at potentials greater than +2.0 V only. Liquid chromatography coupled with mass spectrometry was employed to verify the generation of two primary degradation by-products, namely OP1 (m/z = 319.20) and OP2 (m/z = 247.19). The relative amounts of these degradation products showed variability depending on the diamond electrode used, which was conditioned by different B/C ratios.

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掺硼金刚石电极：研究掺杂水平对药物降解的影响

研究了掺入金刚石电极中的硼含量对活性药物成分阿巴卡韦氧化降解行为的影响。研究了五种硼掺杂金刚石电极的特性，它们的硼/碳掺杂比分别为 500 ppm、1000 ppm、2000 ppm、4000 ppm 和 8000 ppm。在批处理池中研究了阿巴卡韦物质的氧化降解。降解是在电位为 +0.6 V 至 +3.7 V 的恒电位电解条件下进行的。只有在电位大于 +2.0 V 时，硼含量才会对该物质的氧化降解产生显著影响。采用液相色谱-质谱法验证了两种主要降解副产物的生成，即 OP1（m/z = 319.20）和 OP2（m/z = 247.19）。这些降解产物的相对数量随所使用的金刚石电极（以不同的 B/C 比值为条件）的不同而变化。

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Monatshefte für Chemie / Chemical Monthly

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