Binding and dimerization control phase separation in a compartment

Riccardo Rossetto, Gerrit Wellecke, David Zwicker
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Abstract

Biological cells exhibit a hierarchical spatial organization, where various compartments harbor condensates that form by phase separation. Cells can control the emergence of these condensates by affecting compartment size, the amount of the involved molecules, and their physical interactions. While physical interactions directly affect compartment binding and phase separation, they can also cause oligomerization, which has been suggested as a control mechanism. Analyzing an equilibrium model, we illustrate that oligomerization amplifies compartment binding and phase separation, which reinforce each other. This nonlinear interplay can also induce multistability, which provides additional potential for control. Our work forms the basis for deriving thermodynamically consistent kinetic models to understand how biological cells can regulate phase separation in their compartments.
结合和二聚化控制隔室中的相分离
生物细胞呈现出层次分明的空间组织结构,不同的细胞间隙蕴藏着通过相分离形成的凝聚体。细胞可以通过影响隔室的大小、参与分子的数量以及它们之间的物理相互作用来控制这些凝聚体的出现。虽然物理相互作用会直接影响细胞间隙的结合和相分离,但它们也会导致寡聚化,这也被认为是一种控制机制。通过分析一个平衡模型,我们说明了低聚作用会放大区室结合和相分离,从而相互加强。我们的工作为推导热力学上一致的动力学模型奠定了基础,从而了解生物细胞如何调节其区室中的相分离。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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