Nonequilibrium Membrane Dynamics Induced by Active Protein Interactions and Chemical Reactions: A Review

Hiroshi Noguchi
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引用次数: 0

Abstract

Biomembranes wrapping cells and organelles are not only the partitions that separate the insides but also dynamic fields for biological functions accompanied by membrane shape changes. In this review, we discuss the spatiotemporal patterns and fluctuations of membranes under nonequilibrium conditions. In particular, we focus on theoretical analyses and simulations. Protein active forces enhance or suppress the membrane fluctuations; the membrane height spectra are deviated from the thermal spectra. Protein binding or unbinding to the membrane is activated or inhibited by other proteins and chemical reactions, such as ATP hydrolysis. Such active binding processes can induce traveling waves, Turing patterns, and membrane morphological changes. They can be represented by the continuum reaction-diffusion equations and discrete lattice/particle models with state flips. The effects of structural changes in amphiphilic molecules on the molecular-assembly structures are also discussed.
活性蛋白质相互作用和化学反应诱导的非平衡膜动力学:综述
包裹细胞和细胞器的生物膜不仅是分隔内部的隔板,也是伴随膜形状变化的生物功能动态场。在这篇综述中,我们将讨论非平衡条件下膜的时空模式和波动。蛋白质活性力增强或抑制膜波动;膜高度谱偏离热谱。蛋白质与膜的结合或解除结合会被其他蛋白质和化学反应(如 ATP 水解)激活或抑制。这种活跃的结合过程可引发行波、图灵模式和膜形态变化,可用连续反应-扩散方程和具有状态翻转的离散晶格/粒子模型来表示。此外,还讨论了两亲分子结构变化对分子组装结构的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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