Regio- and Chemoselective Synthesis of 4,6-Dithia-1,2,9-triazaspiro[4.4]non-2-en-8-ones through an Ultrasound-Promoted One-Pot Sequential Pseudo-Five-Component Reaction

Synthesis Pub Date : 2024-07-22 DOI:10.1055/s-0043-1775386
Abdolali Alizadeh, Ebrahim Amir Chelebari, Reza Rezaiyehraad
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Abstract

Spiro-heterocycles have attracted significant interest due to their unique biological properties with fewer side effects compared to traditional drugs. Herein, a novel method is reported for the synthesis of a series of spiro-heterocycles possessing a quinoline motif. The strategy utilizes rhodanine derivatives, hydrazonoyl chlorides, and 2-chloroquinoline-3-carbaldehyde, and proceeds via a one-pot sequential pseudo-five-component reaction. The reactions are found to proceed in a regioselective and chemoselective manner.

Abstract Image

通过超声波促进的单锅顺序伪五组分反应,实现 4,6-二硫杂-1,2,9-三氮杂螺[4.4]壬-2-烯-8-酮的区域和化学选择性合成
与传统药物相比,螺环杂环具有独特的生物特性,且副作用较少,因此备受关注。本文报告了一种合成一系列具有喹啉基团的螺环杂环的新方法。该策略利用了罗丹宁衍生物、肼酰氯和 2-氯喹啉-3-甲醛,并通过单锅顺序伪五组分反应进行。研究发现,反应以区域选择性和化学选择性的方式进行。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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