Peter Boehling, Dalibor Jajcevic, Frederik Detobel, James Holman, Laura Bower, Matthew Metzger, Johannes G. Khinast
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引用次数: 0
Abstract
Continuous manufacturing has been increasingly applied in the pharmaceutical industry. The advantages are a more flexible process, decreased costs, and opportunities for better quality control. However, performing experiments is still the way to go when developing a new process but most experiments offer only limited process insight. As part of its ConsiGma® continuous processing lines, GEA has developed a semi-continuous tablet coater with unique design and process mechanics. Simulations enable a deeper understanding of the process mechanics and allow the transition from an empirical process to a mechanistic understanding of the individual process units. We used simulations to improve the understanding of the ConsiGma® tablet coater through a digital multivariate design study. Our simulations demonstrate how the mechanical and material properties influence the tablet bed behavior. We tracked the effects of thermodynamic inputs on the coating quality via the tablet temperature and moisture. These results may be helpful in the future development of coating processes using limited experimental data.
期刊介绍:
GENERAL OBJECTIVES: Computational Particle Mechanics (CPM) is a quarterly journal with the goal of publishing full-length original articles addressing the modeling and simulation of systems involving particles and particle methods. The goal is to enhance communication among researchers in the applied sciences who use "particles'''' in one form or another in their research.
SPECIFIC OBJECTIVES: Particle-based materials and numerical methods have become wide-spread in the natural and applied sciences, engineering, biology. The term "particle methods/mechanics'''' has now come to imply several different things to researchers in the 21st century, including:
(a) Particles as a physical unit in granular media, particulate flows, plasmas, swarms, etc.,
(b) Particles representing material phases in continua at the meso-, micro-and nano-scale and
(c) Particles as a discretization unit in continua and discontinua in numerical methods such as
Discrete Element Methods (DEM), Particle Finite Element Methods (PFEM), Molecular Dynamics (MD), and Smoothed Particle Hydrodynamics (SPH), to name a few.