Umbilical Cord Hemangiomas: A Multi-Institutional Case Series With Literature Review.

IF 1.3 4区 医学 Q3 PATHOLOGY
Elizabeth O Ferreira, Camelia Stefanovici, Stefan Kostadinov, Virginia Duncan
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引用次数: 0

Abstract

Umbilical cord hemangiomas are rare lesions, for which data on pregnancy outcome is lacking. This study combines a multi-institution 4-case series with a systematic literature search (n = 52) to determine possible pathologic lesion parameters which may have an effect on pregnancy outcome. Of all 56 pregnancies, lesion size ranged from 0.2 to 23.0 cm with pregnancy outcomes ranging from healthy liveborns (58.9%), liveborns with severe complications largely due to prematurity and/or fluid overload (12.5%), intrauterine/neonatal demise (25.0%), and pregnancy termination (3.6%). Of the 52 cases included for statistical analysis, there was no significant association between fetal outcome and vascular lesion location (P = .12) or fetal outcome and single umbilical artery involvement versus involvement of other vasculature (P = .29). The mean length of vascular lesions that resulted in healthy liveborns did not significantly differ from those resulting in severe fetal complications and/or demise (P = .72). Cases resulting in severe complications and/or demise were significantly earlier at delivery than those resulting in healthy liveborns (P < .001). Combined findings suggest that functional lesion characteristics, such as the degree of turbulent flow generated, have more significance than size, especially in early gestation losses. Moving forward, standardized reporting of pathologic lesion characteristics is paramount to better predict pregnancy prognosis.

脐带血管瘤:多机构病例系列及文献综述
脐带血管瘤是一种罕见病变,目前尚缺乏有关妊娠结局的数据。本研究将多机构的 4 例系列研究与系统性文献检索(n = 52)相结合,以确定可能对妊娠结局产生影响的病理病变参数。在所有 56 例妊娠中,病灶大小从 0.2 厘米到 23.0 厘米不等,妊娠结局包括健康活产(58.9%)、主要因早产和/或体液过多导致严重并发症的活产(12.5%)、宫内/新生儿死亡(25.0%)和妊娠终止(3.6%)。在纳入统计分析的52例病例中,胎儿结局与血管病变位置(P = .12)或胎儿结局与单根脐动脉受累与其他血管受累(P = .29)之间无明显关联。导致健康活产的血管病变的平均长度与导致严重胎儿并发症和/或死亡的血管病变的平均长度没有显著差异(P = .72)。导致严重并发症和/或夭折的病例的分娩时间明显早于导致健康活产儿的病例(P = 0.29)。
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来源期刊
CiteScore
3.70
自引率
5.30%
发文量
59
审稿时长
6-12 weeks
期刊介绍: The Journal covers the spectrum of disorders of early development (including embryology, placentology, and teratology), gestational and perinatal diseases, and all diseases of childhood. Studies may be in any field of experimental, anatomic, or clinical pathology, including molecular pathology. Case reports are published only if they provide new insights into disease mechanisms or new information.
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