The Effect of Microvascular Invasion on Hepatocellular Carcinoma With Portal Vein Tumor Thrombus After Hepatectomy: A Retrospective Study.

IF 2.5 4区医学 Q3 ONCOLOGY

Cancer Control Pub Date : 2024-01-01 DOI:10.1177/10732748241265257

Qingyi Xu, Liqin Lan, Jinhua Zeng, Jianxing Zeng

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引用次数: 0

Abstract

Background: There is no report resolving whether microvascular invasion (MVI) affects the prognosis of hepatectomy for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT). The present study aimed to investigate the effect of MVI on HCC with PVTT after hepatectomy.

Methods: 362 HCC patients with PVTT were included in this retrospective study. Diagnostic criteria of PVTT in HCC patients were based on typical preoperative radiological features on imaging studies. The log-rank test was utilized to differentiate overall survival (OS) and recurrence-free survival (RFS) rates between the two groups. Univariate and multivariate Cox proportional hazard regression was utilized to detect independent factors.

Results: PVTT without MVI accounted for 12.2% (n = 44). PVTT without MVI groups was significantly superior to PVTT with MVI groups in OS (the median survival = 27.1 months vs 13.7 months) and RFS (the median survival = 6.4 months vs 4.1 months). The 1-, 3-, and 5-year OS rates (65.5%, 36.8%, 21.7% vs 53.5%, 18.7%, 10.1%, P = .014) and RFS rates (47.0%, 29.7%, 19.2% vs 28.7%, 12.2%, 6.9%, P = .005) were significant different between two groups. Multivariate analysis showed that MVI was an independent risk factor for OS (hazard ratio (HR) = 1.482; P-value = .045) and RFS (HR = 1.601; P-value = .009).

Conclusions: MVI was an independent prognostic factor closely linked to tumor recurrence and poorer clinical outcomes for HCC patients with PVTT after hepatectomy. MVI should be included in current PVTT systems to supplement to the PVTT type.

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微血管侵犯对肝切除术后伴有门静脉瘤栓的肝细胞癌的影响：一项回顾性研究

背景：微血管侵犯（MVI）是否会影响伴有门静脉肿瘤血栓（PVTT）的肝细胞癌（HCC）患者肝切除术的预后，目前尚无相关报道。本研究旨在探讨 MVI 对肝切除术后伴有 PVTT 的 HCC 的影响。HCC患者PVTT的诊断标准基于术前影像学检查的典型放射学特征。采用对数秩检验来区分两组患者的总生存率（OS）和无复发生存率（RFS）。利用单变量和多变量考克斯比例危险回归检测独立因素：结果：无 MVI 的 PVTT 占 12.2%（n = 44）。在OS（中位生存期=27.1个月 vs 13.7个月）和RFS（中位生存期=6.4个月 vs 4.1个月）方面，无MVI的PVTT组明显优于有MVI的PVTT组。两组间的 1、3 和 5 年 OS 率（65.5%、36.8%、21.7% vs 53.5%、18.7%、10.1%，P = .014）和 RFS 率（47.0%、29.7%、19.2% vs 28.7%、12.2%、6.9%，P = .005）差异显著。多变量分析显示，MVI是OS（危险比（HR）=1.482；P值=0.045）和RFS（HR=1.601；P值=0.009）的独立危险因素：结论：MVI是一个独立的预后因素，与肝切除术后PVTT的HCC患者的肿瘤复发和较差的临床预后密切相关。MVI应纳入目前的PVTT系统，作为PVTT类型的补充。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Control ONCOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

148

审稿时长

>12 weeks

期刊介绍： Cancer Control is a JCR-ranked, peer-reviewed open access journal whose mission is to advance the prevention, detection, diagnosis, treatment, and palliative care of cancer by enabling researchers, doctors, policymakers, and other healthcare professionals to freely share research along the cancer control continuum. Our vision is a world where gold-standard cancer care is the norm, not the exception.

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