Association Between Heart Rate at Diagnosis and Long-Term Recurrence Risk of Pulmonary Embolism in a Historical Cohort Study of Elder Women.

IF 2.3 4区 医学 Q2 HEMATOLOGY
Yuan Li, Fang Li, Meizhi Li, Qiong Yi, Shangjie Wu
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引用次数: 0

Abstract

To investigate the association between heart rate (HR) at diagnosis and long-term pulmonary embolism (PE) recurrence among elderly (≥ 50 year-old) female patients after acute PE (APE). Hospitalized patients with APE were grouped separately according to whether they experienced recurrent PE and whether the HR was  < 80 beats/min. Logistic regression and COX regression analysis were employed to assess the risk of PE recurrence. Kaplan-Meier method was applied to compare the recurrence-free survival of PE recurrence. Eighty-five patients were included, including 24 ones with HR < 80 beats/min and 11 recurrent PE cases. The mean time of PE recurrence were 71.7 ± 26.9 months (n = 6) and 27.7 ± 25.2 months (n = 5) among the patients with low HR and with high HR, respectively (P < .001). The HR (< 80 beats/min) was a negative predictor of PE recurrence (OR 0.071 (0.090-0.572), P = .013; HR 0.091 (0.016-0.523), P = .007), even after the adjustment for age, BMI, albumin, risk stratification, surgery, immobility ≥ 4 days, the blood cells counts, bilirubin and complications. The cumulative recurrence-free rates of PE recurrence at the 1st-, 2nd-, 5th-, and 10th-years for the low HR group were 100%, 100%, 87.5%, and 58.3%, compared to the 1st-, 2nd-, and 3rd-years of 94.0%, 93.4%, and 48.0% for the high HR group (log-rank = 0.019). The low HR (< 80 beats/min at diagnosis) among elderly (≥ 50 years old) female patients at APE diagnosis would benefit to the long-term PE recurrence. But limited recurrent cases should be noted.

老年妇女历史队列研究中确诊时的心率与肺栓塞长期复发风险之间的关系
研究急性肺栓塞(APE)后老年(≥ 50 岁)女性患者诊断时的心率(HR)与长期肺栓塞(PE)复发之间的关系。即使在调整了年龄、体重指数(BMI)、白蛋白、风险分层、手术、活动时间≥4 天、血细胞计数、胆红素和并发症后,APE 住院患者仍根据其是否经历过复发 PE 以及 HR 是否为 P P = .013; HR 0.091 (0.016-0.523), P = .007) 分别进行分组。低HR组第1年、第2年、第5年和第10年的累计无PE复发率分别为100%、100%、87.5%和58.3%,而高HR组第1年、第2年和第3年的累计无PE复发率分别为94.0%、93.4%和48.0%(log-rank = 0.019)。老年(≥ 50 岁)女性患者在确诊 APE 时心率较低(确诊时心率< 80 次/分),这将有利于 PE 的长期复发。但应注意复发病例有限。
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来源期刊
CiteScore
4.40
自引率
3.40%
发文量
150
审稿时长
2 months
期刊介绍: CATH is a peer-reviewed bi-monthly journal that addresses the practical clinical and laboratory issues involved in managing bleeding and clotting disorders, especially those related to thrombosis, hemostasis, and vascular disorders. CATH covers clinical trials, studies on etiology, pathophysiology, diagnosis and treatment of thrombohemorrhagic disorders.
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