The Evolving Function of Vasculature and Pro-angiogenic Therapy in Fat Grafting.

IF 3.2 4区医学 Q3 CELL & TISSUE ENGINEERING

Cell Transplantation Pub Date : 2024-01-01 DOI:10.1177/09636897241264976

Zhang Xining, Luo Sai

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引用次数: 0

Abstract

Autologous fat grating is a widely-accepted method to correct soft tissue deficiency. Although fat transplantation shows excellent biocompatibility and simple applicability, the relatively low retention rate caused by fat necrosis is still a challenge. The vasculature is integral after fat grafting, serving multiple crucial functions. Rapid and effective angiogenesis within grafts is essential for supplying oxygen necessary for adipocytes' survival. It facilitates the influx of inflammatory cells to remove necrotic adipocytes and aids in the delivery of regenerative cells for adipose tissue regeneration in fat grafts. The vasculature also provides a niche for interaction between adipose progenitor cells and vascular progenitor cells, enhancing angiogenesis and adipogenesis in grafts. Various methods, such as enriching grafts with diverse pro-angiogenic cells or utilizing cell-free approaches, have been employed to enhance angiogenesis. Beige and dedifferentiated adipocytes in grafts could increase vessel density. This review aims to outline the function of vasculature in fat grafting and discuss different cell or cell-free approaches that can enhance angiogenesis following fat grafting.

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脂肪移植中不断演变的血管功能和促血管生成疗法。

自体脂肪格栅是一种广泛接受的矫正软组织缺损的方法。虽然脂肪移植具有良好的生物相容性和简单的适用性，但因脂肪坏死而导致的相对较低的保留率仍是一个挑战。血管是脂肪移植后不可或缺的部分，具有多种重要功能。移植物内快速有效的血管生成对于提供脂肪细胞存活所需的氧气至关重要。它有助于炎症细胞的涌入，以清除坏死的脂肪细胞，并帮助输送再生细胞，促进脂肪移植物中脂肪组织的再生。血管还为脂肪祖细胞和血管祖细胞之间的相互作用提供了一个龛位，从而增强移植物的血管生成和脂肪生成。目前已采用多种方法来增强血管生成，例如用不同的促血管生成细胞富集移植物或利用无细胞方法。移植物中的米色和去分化脂肪细胞可增加血管密度。本综述旨在概述脂肪移植中血管的功能，并讨论脂肪移植后可增强血管生成的不同细胞或无细胞方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Transplantation 生物-细胞与组织工程

CiteScore

6.00

自引率

3.00%

发文量

审稿时长

6 months

期刊介绍： Cell Transplantation, The Regenerative Medicine Journal is an open access, peer reviewed journal that is published 12 times annually. Cell Transplantation is a multi-disciplinary forum for publication of articles on cell transplantation and its applications to human diseases. Articles focus on a myriad of topics including the physiological, medical, pre-clinical, tissue engineering, stem cell, and device-oriented aspects of the nervous, endocrine, cardiovascular, and endothelial systems, as well as genetically engineered cells. Cell Transplantation also reports on relevant technological advances, clinical studies, and regulatory considerations related to the implantation of cells into the body in order to provide complete coverage of the field.