Peter T. Chivers , Priyanka Basak , Michael J. Maroney
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引用次数: 0
Abstract
Biological environments present a complex array of metal-binding ligands. Metal-binding proteins have been the overwhelming focus of study because of their important and well-defined biological roles. Consequently, the presence of functional low molecular weight (LMW) metal-ligand complexes has been overlooked in terms of their roles in metallobiochemistry, particularly within cells. Recent studies in microbial systems have illuminated the different roles of L-histidine in nickel uptake, gene expression, and metalloenzyme maturation. In this focused critical review, these roles are surveyed in the context of the coordination chemistry of Ni(II) ions and the amino acid histidine, and the physico-chemical properties of nickel complexes of histidine. These complexes are fundamentally important to cellular metal homeostasis and further work is needed to fully define their contributions.
生物环境中存在着一系列复杂的金属结合配体。由于金属结合蛋白具有重要而明确的生物学作用，它们一直是研究的重点。因此，人们忽视了功能性低分子量（LMW）金属配体复合物在金属生物化学中的作用，尤其是在细胞内的作用。最近在微生物系统中进行的研究揭示了 L 组氨酸在镍吸收、基因表达和金属酶成熟中的不同作用。在这篇重点突出的综述中，将从 Ni(II) 离子与组氨酸的配位化学以及组氨酸镍络合物的物理化学性质的角度对这些作用进行考察。这些络合物对细胞的金属平衡具有根本性的重要意义，需要进一步的工作来全面确定它们的贡献。
期刊介绍：
The Journal of Inorganic Biochemistry is an established international forum for research in all aspects of Biological Inorganic Chemistry. Original papers of a high scientific level are published in the form of Articles (full length papers), Short Communications, Focused Reviews and Bioinorganic Methods. Topics include: the chemistry, structure and function of metalloenzymes; the interaction of inorganic ions and molecules with proteins and nucleic acids; the synthesis and properties of coordination complexes of biological interest including both structural and functional model systems; the function of metal- containing systems in the regulation of gene expression; the role of metals in medicine; the application of spectroscopic methods to determine the structure of metallobiomolecules; the preparation and characterization of metal-based biomaterials; and related systems. The emphasis of the Journal is on the structure and mechanism of action of metallobiomolecules.
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