STING: Stay near to STIM(1) neuroprotection

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-07-25 DOI:10.1016/j.molcel.2024.06.034

引用次数: 0

Abstract

In a recent publication in Cell, Woo et al.¹ report that stimulator of interferon genes (STING) links inflammation with glutamate-driven excitotoxicity to induce ferroptosis, identifying a mechanism of inflammation-induced neurodegeneration and also a novel candidate therapeutic target for multiple sclerosis.

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STING：靠近 STIM(1) 神经保护装置

在最近发表于《细胞》（Cell）的一篇文章中，Woo 等人1 报告说，干扰素基因刺激器（STING）将炎症与谷氨酸驱动的兴奋毒性联系起来，诱导铁变态反应，从而确定了炎症诱导神经退行性变的机制，也是多发性硬化症的一个新的候选治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.