ASSOCIATION BETWEEN ANXIETY AND DEPRESSION IN METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD).

Q2 Medicine

Arquivos de Gastroenterologia Pub Date : 2024-07-19 eCollection Date: 2024-01-01 DOI:10.1590/S0004-2803.24612023-128

Eloyse Cristina Botacin, Sebastião Mauro Bezerra Duarte, José Tadeu Stefano, Mary Ellen Dias Barbosa, Mario Guimarães Pessoa, Cláudia P Oliveira

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引用次数: 0

Abstract

Background: This study aimed to assess the frequency and intensity of anxious and depressive symptoms in patients diagnosed with metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods: This is a descriptive and cross-sectional study, resulting from 106 patients from the Hepatology outpatient clinic at the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), São Paulo, Brazil without a history of alcohol abuse, verified by the alcohol use disorders identification test (AUDIT). These were assessed using the sociodemographic data sheet, Hospital Anxiety and Depression Scale (HADS), Hamilton Anxiety Rating Scale (HAM-A), and Hamilton Depression Scale (HAM-D).

Results: A total of 69.8% were women and 30.2% were men, with a mean age of 61 years. The majority (71.7%) discovered MASLD through routine exams, presenting as comorbidities: Type 2 diabetes mellitus (59.4%), Dyslipidemia (49.1%), Arterial hypertension (68.9%), Obesity (61.3%) and Metabolic syndrome [MetS (63.2%)]. The HADS scale indicates 34% probability of anxiety and 33% depressive symptoms. The Hamilton's scales of intensity indicates 63.9% severe anxiety and 54.3% severe depression. There is also a relationship between anxiety, depression and the female gender, as well as between depression and MetS.

Conclusion: The findings point to the presence of anxiety and depression in more than one third of MASLD patients, most with severe symptoms. The group is concentrated in the elderly, with many comorbidities, including MetS. There was a positive correlation between anxiety, depression and being female; also, being significant between MetS and depression.

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代谢功能障碍相关性脂肪性肝病（MASLD）中焦虑与抑郁之间的关系。

研究背景本研究旨在评估被诊断为代谢功能障碍相关性脂肪性肝病（MASLD）患者的焦虑和抑郁症状的频率和强度：这是一项描述性横断面研究，来自巴西圣保罗圣保罗大学医学院附属医院（HC-FMUSP）肝病门诊的106名患者均无酗酒史，并通过酒精使用障碍识别测试（AUDIT）进行了验证。研究人员使用社会人口学数据表、医院焦虑抑郁量表（HADS）、汉密尔顿焦虑评定量表（HAM-A）和汉密尔顿抑郁量表（HAM-D）对这些数据进行了评估：女性占 69.8%，男性占 30.2%，平均年龄 61 岁。大多数人（71.7%）是通过常规检查发现 MASLD 的，表现为合并症：2型糖尿病（59.4%）、血脂异常（49.1%）、动脉高血压（68.9%）、肥胖（61.3%）和代谢综合征[MetS（63.2%）]。HADS 量表显示，34% 的人可能有焦虑症状，33% 的人有抑郁症状。汉密尔顿强度量表显示，63.9%的人有严重焦虑，54.3%的人有严重抑郁。焦虑、抑郁与女性性别之间以及抑郁与 MetS 之间也存在关系：研究结果表明，三分之一以上的 MASLD 患者患有焦虑症和抑郁症，其中大多数症状严重。该群体主要集中在老年人中，有许多合并症，包括代谢综合征。焦虑、抑郁与女性之间存在正相关；MetS与抑郁之间也存在显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivos de Gastroenterologia Medicine-Gastroenterology

CiteScore

2.00

自引率

0.00%

发文量

109

审稿时长

9 weeks

期刊介绍： The journal Arquivos de Gastroenterologia (Archives of Gastroenterology), a quarterly journal, is the Official Publication of the Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia IBEPEGE (Brazilian Institute for Studies and Research in Gastroenterology), Colégio Brasileiro de Cirurgia Digestiva - CBCD (Brazilian College of Digestive Surgery) and of the Sociedade Brasileira de Motilidade Digestiva - SBMD (Brazilian Digestive Motility Society). It is dedicated to the publishing of scientific papers by national and foreign researchers who are in agreement with the aim of the journal as well as with its editorial policies.