Atherogenic markers and 1-year amputation risk in adults with diabetic foot in a tertiary level hospital: A retrospective cohort study

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2024-07-16 DOI:10.1016/j.jdiacomp.2024.108810

Jerry K. Benites-Meza , Jussara Malo-Castillo , Percy Herrera-Añazco , Vicente A. Benites-Zapata

{"title":"Atherogenic markers and 1-year amputation risk in adults with diabetic foot in a tertiary level hospital: A retrospective cohort study","authors":"Jerry K. Benites-Meza , Jussara Malo-Castillo , Percy Herrera-Añazco , Vicente A. Benites-Zapata","doi":"10.1016/j.jdiacomp.2024.108810","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><p>To determine the association between atherogenic markers, such as total cholesterol/high density lipoprotein cholesterol ratio (TC/HDL-C), triglycerides/HDL-C ratio (TG/HDL-C), and triglycerides-glucose index (TyG), and the risk of 1-year amputation in adults with diabetic foot in a tertiary level hospital.</p></div><div><h3>Methods</h3><p>Retrospective cohort study conducted in 162 adult patients with diabetic foot. The outcome was amputation, defined as “primary amputation in patients' clinical history after their first hospitalization due to foot ulcer.”. The cutoff point was determined using Youden's J statistic. The relative risk (RR) was presented as an association measure.</p></div><div><h3>Results</h3><p>A TyG index of >9.4 [RR: 1.64 (1.10–2.45)] was associated with a high risk of amputation after 1-year in adults with diabetic foot. However, while a TC/HDL ratio of >4.69 [RR: 1.38 (0.94–2.03)] and a TG/HDL-C ratio > 3.57 [RR: 1.35 (0.89–2.06)] did not show associations with risk of amputation after 1-year.</p></div><div><h3>Conclusions</h3><p>Only a TyG index of >9.4 was associated with an increased risk of 1-year amputation in adults with diabetic foot. Future studies with larger samples and a longitudinal design may provide more robust evidence and a better understanding of clinical implications.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 9","pages":"Article 108810"},"PeriodicalIF":2.9000,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of diabetes and its complications","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1056872724001363","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Aim

To determine the association between atherogenic markers, such as total cholesterol/high density lipoprotein cholesterol ratio (TC/HDL-C), triglycerides/HDL-C ratio (TG/HDL-C), and triglycerides-glucose index (TyG), and the risk of 1-year amputation in adults with diabetic foot in a tertiary level hospital.

Methods

Retrospective cohort study conducted in 162 adult patients with diabetic foot. The outcome was amputation, defined as “primary amputation in patients' clinical history after their first hospitalization due to foot ulcer.”. The cutoff point was determined using Youden's J statistic. The relative risk (RR) was presented as an association measure.

Results

A TyG index of >9.4 [RR: 1.64 (1.10–2.45)] was associated with a high risk of amputation after 1-year in adults with diabetic foot. However, while a TC/HDL ratio of >4.69 [RR: 1.38 (0.94–2.03)] and a TG/HDL-C ratio > 3.57 [RR: 1.35 (0.89–2.06)] did not show associations with risk of amputation after 1-year.

Conclusions

Only a TyG index of >9.4 was associated with an increased risk of 1-year amputation in adults with diabetic foot. Future studies with larger samples and a longitudinal design may provide more robust evidence and a better understanding of clinical implications.

查看原文本刊更多论文

一家三级医院成人糖尿病足患者的致动脉粥样硬化标志物和 1 年截肢风险：一项回顾性队列研究。

目的：确定总胆固醇/高密度脂蛋白胆固醇比值（TC/HDL-C）、甘油三酯/高密度脂蛋白胆固醇比值（TG/HDL-C）和甘油三酯-葡萄糖指数（TyG）等致动脉粥样硬化指标与一家三级医院成人糖尿病足患者1年截肢风险之间的关系：对 162 名成年糖尿病足患者进行回顾性队列研究。研究结果为截肢，其定义为 "患者因足部溃疡首次住院后的临床病史中的初次截肢"。截肢点采用尤登 J 统计法确定。结果显示，相对风险（RR）为关联测量值：结果：TyG 指数大于 9.4 [RR：1.64 (1.10-2.45)]与成人糖尿病足患者 1 年后截肢的高风险相关。然而，TC/HDL 比率大于 4.69 [RR: 1.38 (0.94-2.03)] 和 TG/HDL-C 比率大于 3.57 [RR: 1.35 (0.89-2.06)] 与 1 年后截肢风险无关：结论：只有 TyG 指数大于 9.4 才与成人糖尿病足患者 1 年后截肢风险增加有关。未来采用更大样本和纵向设计的研究可能会提供更有力的证据，并更好地理解临床影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.