Transition metal complexes of hydrazones as potential antimicrobial and anticancer agents: A short review

IF 3.2 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Izabela Czyżewska, Liliana Mazur, Łukasz Popiołek
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引用次数: 0

Abstract

Hydrazones display an interesting profile of biological activities, which includes mainly antimicrobial and antiproliferative properties. Hydrazones also play an important role in the synthesis of heterocyclic rings and in coordination chemistry. Currently, the synthesis of complexes of hydrazones with transition metals is quite frequently reported in the scientific literature. The interest in this topic is largely due to diverse biological activities of the metal complexes of hydrazones that in some cases are much more effective than hydrazones themselves. This review focuses on the complexes of hydrazones with transition metals which display antibacterial, antitubercular, antifungal and anticancer activities. In the following subchapters devoted to a given activity, an attempt has been made to present the most active complexes of hydrazones, their trends in their activity and application in medicinal chemistry. The paper presents the literature data from 2009 to 2023. This review constitutes a useful guide for the researchers who intend to synthesize and investigate complexes of hydrazones in terms of their antimicrobial and anticancer activities.

Abstract Image

作为潜在抗菌剂和抗癌剂的肼的过渡金属配合物:简评。
肼酮具有有趣的生物活性,主要包括抗菌和抗增殖特性。肼酮类化合物在合成杂环和配位化学中也发挥着重要作用。目前,科学文献中关于肼酮与过渡金属的络合物合成的报道相当频繁。人们之所以对这一主题感兴趣,主要是因为肼酮的金属络合物具有多种生物活性,在某些情况下比肼酮本身更有效。本综述重点介绍了具有抗菌、抗结核、抗真菌和抗癌活性的肼酮与过渡金属的配合物。在接下来专门讨论特定活性的各小节中,我们试图介绍最具活性的肼酮类络合物、其活性趋势以及在药物化学中的应用。本文介绍了 2009 年至 2023 年的文献数据。这篇综述为有意合成和研究肼酮类复合物抗菌和抗癌活性的研究人员提供了有用的指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Chemical Biology & Drug Design
Chemical Biology & Drug Design 医学-生化与分子生物学
CiteScore
5.10
自引率
3.30%
发文量
164
审稿时长
4.4 months
期刊介绍: Chemical Biology & Drug Design is a peer-reviewed scientific journal that is dedicated to the advancement of innovative science, technology and medicine with a focus on the multidisciplinary fields of chemical biology and drug design. It is the aim of Chemical Biology & Drug Design to capture significant research and drug discovery that highlights new concepts, insight and new findings within the scope of chemical biology and drug design.
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