{"title":"The conditional barycenter problem, its data-driven formulation and its solution through normalizing flows","authors":"Esteban G. Tabak, Giulio Trigila, Wenjun Zhao","doi":"10.4310/cms.2024.v22.n6.a8","DOIUrl":null,"url":null,"abstract":"A family of normalizing flows is introduced for selectively removing from a data set the variability attributable to a specific set of cofactors, while preserving the dependence on others. This is achieved by extending the barycenter problem of optimal transport theory to the newly introduced conditional barycenter problem. Rather than summarizing the data with a single probability distribution, as in the classical barycenter problem, the conditional barycenter is represented by a family of distributions labeled by the cofactors kept. The use of the conditional barycenter and its differences with the classical barycenter are illustrated on synthetic and real data addressing treatment effect estimation, super-resolution, anomaly detection and lightness transfer in image analysis.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"100","ListUrlMain":"https://doi.org/10.4310/cms.2024.v22.n6.a8","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A family of normalizing flows is introduced for selectively removing from a data set the variability attributable to a specific set of cofactors, while preserving the dependence on others. This is achieved by extending the barycenter problem of optimal transport theory to the newly introduced conditional barycenter problem. Rather than summarizing the data with a single probability distribution, as in the classical barycenter problem, the conditional barycenter is represented by a family of distributions labeled by the cofactors kept. The use of the conditional barycenter and its differences with the classical barycenter are illustrated on synthetic and real data addressing treatment effect estimation, super-resolution, anomaly detection and lightness transfer in image analysis.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.