Deoxygenative Functionalizations of Aromatic Dicarbonyls and Aldehydes

IF 3.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Bulletin of the Chemical Society of Japan Pub Date : 2024-07-19 DOI:10.1093/bulcsj/uoae078

Moriaki Sakihara, Shuhei Shimoyama, Miki B Kurosawa, Junichiro Yamaguchi

引用次数: 0

Abstract

In this study, we developed a method to synthesize deoxygenative functionalized products by reacting aromatic dicarbonyls with DBU, TMSOTf, diphenylphosphine oxide, and a range of nucleophiles. Moreover, we demonstrated that sequential application of phospha-Brook rearrangement and benzylic substitution conditions to aromatic aldehydes affords the deoxygenative functionalized products effectively. With highly nucleophilic reagents, it was possible to proceed with the deoxygenative functionalization without TMSOTf.

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芳香族二羰基和醛的脱氧功能化

在这项研究中，我们开发了一种方法，通过芳香族二羰基与 DBU、TMSOTf、二苯基氧化膦和一系列亲核剂反应，合成脱氧功能化产物。此外，我们还证明了在芳香醛中连续应用磷-布鲁克重排和苄基取代条件可以有效地得到脱氧官能化产物。在使用高亲核试剂时，可以不使用 TMSOTf 进行脱氧官能化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of the Chemical Society of Japan 化学-化学综合

CiteScore

6.40

自引率

5.00%

发文量

194

审稿时长

3-8 weeks

期刊介绍： The Bulletin of the Chemical Society of Japan (BCSJ) is devoted to the publication of scientific research papers in the fields of Theoretical and Physical Chemistry, Analytical and Inorganic Chemistry, Organic and Biological Chemistry, and Applied and Materials Chemistry. BCSJ appears as a monthly journal online and in advance with three kinds of papers (Accounts, Articles, and Short Articles) describing original research. The purpose of BCSJ is to select and publish the most important papers with the broadest significance to the chemistry community in general. The Chemical Society of Japan hopes all visitors will notice the usefulness of our journal and the abundance of topics, and welcomes more submissions from scientists all over the world.

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